Gadolinium doped red-emissive carbon dots as targeted theranostic agents for fluorescence and MR imaging guided cancer phototherapy

“…In a study carried out by Jiao et al., the researchers prepared Gd‐CDs through a facile solvothermal approach for fluorescence (FL)/MR imaging guided phototherapy (Figure 4a) [103] . The Gd‐CDs presented broad absorbance from UV to NIR range and strong red‐fluorescence emission with a calculated QY of 5.6 %.…”

Section: M‐cds For Versatile Bio‐applicationsmentioning

confidence: 99%

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Qian

et al. 2022

ChemMedChem

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Metal ions possess abundant electrons and unoccupied orbitals, as well as large atomic radii, whose doping into carbon dots (CDs) is a facile strategy to endow CDs with additional physicochemical characteristics. After being doped with metal ions, CDs reveal obvious changes in their optical, electronic, and magnetic properties by adjustments to their electron density distribution and the energy gaps, leading them to be promising and competitive candidates as labeling probes, imaging agents, catalysts, nanodrugs, and so on. In this review, we summarize the fabrication methods of metal‐ion‐doped CDs (M‐CDs), and highlight their biological applications including biosensing, bioimaging, tumor therapy, and anti‐microbial treatment. Finally, the challenging future perspectives of M‐CDs are analyzed. We hope this review will provide inspiration for further development of M‐CDs in various biological aspects, and help readers who are interested in M‐CDs and their biological applications.

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“…The antibacterial mechanism involved in CD administration is a complex and disparate process from conventional antibiotics [ 13 ]. CDs inhibit bacterial growth and destroy cells through complex mechanisms (photothermal sterilization [ 14 ], photodynamic sterilization [ 15 , 16 ], and DNA degradation [ 17 ]) and are therefore unlikely to develop resistance.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Ciprofloxacin-Based Carbon Dots with High Antibacterial Activity

Miao

Wang

Cong

et al. 2023

IJMS

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Nowadays, bacterial infections are attracting great attention for the research and development of new antimicrobial agents. As one of the quinolones, ciprofloxacin (CI) has a broad-spectrum, strong antibacterial effect. However, the clinical use of ciprofloxacin is limited by drug resistance. Ciprofloxacin carbon dots (CCDs) with enhanced antibacterial activity and copper-doped ciprofloxacin carbon dots (Cu-CCDs) were synthesized by a simple hydrothermal method. The results of structural analysis and antibacterial experiments show that CCDs and Cu-CCDs have effective antibacterial properties by retaining the active groups of ciprofloxacin (-COOH, C-N, and C-F), and Cu-CCDs doped with copper have a better antibacterial effect. In addition, experiments have shown that Cu-CCDs show excellent antibacterial activity against E. coli and S. aureus and have good biocompatibility, which indicates that they have great prospects in clinical applications. Therefore, novel modified copper CCDs with broad-spectrum antibacterial activity, which can be used as antibacterial nanomaterials for potential applications in the field of antibacterial drugs, were synthesized in this study.

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Gadolinium doped red-emissive carbon dots as targeted theranostic agents for fluorescence and MR imaging guided cancer phototherapy

Cited by 43 publications

References 41 publications

Recent developments in carbon dots: a biomedical application perspective

Recent developments in carbon dots: a biomedical application perspective

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Preparation of Ciprofloxacin-Based Carbon Dots with High Antibacterial Activity

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