Gadolinium-doped carbon dots as nano-theranostic agents for MR/FL diagnosis and gene delivery

He, Xi; Luo, Qiang; Zhang, Ji; Chen, Ping; Wang, Haijiao; Luo, Kui; Yu, Xiao‐Qi

doi:10.1039/c9nr03988k

Cited by 54 publications

(30 citation statements)

References 30 publications

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“…The high-resolution XPS spectra of C 1s (Fig. 2d ) revealed the presence of sp3 and sp2 hybridized carbon atoms and carboxylate/hydroxyl moieties in the composite [ 38 ]. The fitted peaks in N 1s spectra suggest the C–N, C=N, and graphitic-N content are involved in the composite.…”

Section: Resultsmentioning

confidence: 99%

Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

Zhang

Zhou

et al. 2022

J Mater Sci: Mater Med

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The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS. The content of Mn2+ is calculated through the EDS and TGA. The quantum yield (QY) and emission wavelength of the probe are about 7.24% and 490 nm, respectively. The longitudinal r1 value (2.43 mM−1 s−1) with low r2/r1 (4.45) of the probe is obtained. Subsequently, fluorescence and MR imaging are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. Thus, these results indicate that probe would be an excellent dual-modal imaging probe for enhanced MR imaging and fluorescence imaging.

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Section: Resultsmentioning

confidence: 99%

Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

Zhang

Zhou

et al. 2022

J Mater Sci: Mater Med

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“…There are very few reports on red-emitting CDs based logic gates. Recently, Gadolinium-doped [81] and holmium-doped CDs were used as contrast agents for generating MRI signals, to construct the dual emission mode CDs based logic gates. Both of them are unsuitable for biological applications due to the toxicity issues, hence it is essential to synthesize a biocompatible contrast agent.…”

Section: Discussionmentioning

confidence: 99%

Carbon Dots-Based Logic Gates

et al. 2021

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Carbon dots (CDs)-based logic gates are smart nanoprobes that can respond to various analytes such as metal cations, anions, amino acids, pesticides, antioxidants, etc. Most of these logic gates are based on fluorescence techniques because they are inexpensive, give an instant response, and highly sensitive. Computations based on molecular logic can lead to advancement in modern science. This review focuses on different logic functions based on the sensing abilities of CDs and their synthesis. We also discuss the sensing mechanism of these logic gates and bring different types of possible logic operations. This review envisions that CDs-based logic gates have a promising future in computing nanodevices. In addition, we cover the advancement in CDs-based logic gates with the focus of understanding the fundamentals of how CDs have the potential for performing various logic functions depending upon their different categories.

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“…Apart from luminescence-based imaging, CDs-based gene carriers can also be designed to achieve multi-modal imaging. For example, He et al fabricated novel Gd-doped CDs grafted with cationic polymers to achieve the combined gene delivery and magnetic resonance (MR)/fluorescence dual modal imaging [ 376 ]. The multifunctional CDs showed much higher transfection efficiency than PEI 25 kDa and could realize spatiotemporal monitoring of the gene delivery process via fluorescence imaging.…”

Section: Nanoparticles-based Delivery Of Tosmentioning

confidence: 99%

Delivery of therapeutic oligonucleotides in nanoscale

Zhou

Lin

et al. 2022

Bioactive Materials

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Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in the targeted cancer treatment due to their high specificity and capability of modulating cellular pathways that are not readily druggable. However, efficiently delivering of TOs to cancer cellular targets is still the biggest challenge in promoting their clinical translations. Emerging as a significant drug delivery vector, nanoparticles (NPs) can not only protect TOs from nuclease degradation and enhance their tumor accumulation, but also can improve the cell uptake efficiency of TOs as well as the following endosomal escape to increase the therapeutic index. Furthermore, targeted and on-demand drug release of TOs can also be approached to minimize the risk of toxicity towards normal tissues using stimuli-responsive NPs. In the past decades, remarkable progresses have been made on the TOs delivery based on various NPs with specific purposes. In this review, we will first give a brief introduction on the basis of TOs as well as the action mechanisms of several typical TOs, and then describe the obstacles that prevent the clinical translation of TOs, followed by a comprehensive overview of the recent progresses on TOs delivery based on several various types of nanocarriers containing lipid-based nanoparticles, polymeric nanoparticles, gold nanoparticles, porous nanoparticles, DNA/RNA nanoassembly, extracellular vesicles, and imaging-guided drug delivery nanoparticles.

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Gadolinium-doped carbon dots as nano-theranostic agents for MR/FL diagnosis and gene delivery

Abstract: Multi-functional carbon dots with MR/FL dual-imaging and gene delivery abilities were constructed for in vitro and in vivo applications.

Cited by 54 publications

References 30 publications

Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

Carbon Dots-Based Logic Gates

Delivery of therapeutic oligonucleotides in nanoscale

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