Gadolinium-based contrast agents

Leyba, Katarina; Wagner, Brent

doi:10.1097/mnh.0000000000000475

Cited by 31 publications

(11 citation statements)

References 28 publications

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“… [129] CMR contrast dye (i.e., gadolinium) should be use with caution in patients with severe kidney insufficiency, as this may increase the risk of nephrogenic systemic fibrosis. [130] CMR nephrogenic systemic fibrosis can occur months after exposure and may be manifest by erythematous and edematous skin plaques mainly to the extremities, joint contractures, and respiratory failure. Beyond renal dysfunction, other risk factors for gadolinium-based contrast nephrogenic systemic fibrosis include proinflammatory state (e.g., major surgery, infection, malignancy), thrombotic events, and high-dose erythropoietin dose.…”

Section: Imaging Studiesmentioning

confidence: 99%

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

Bays

Khera

Blaha³

et al. 2021

American Journal of Preventive Cardiology

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Knowing the patient's current cardiovascular disease (CVD) status, as well as the patient's current and future CVD risk, helps the clinician make more informed patient-centered management recommendations towards the goal of preventing future CVD events. Imaging tests that can assist the clinician with the diagnosis and prognosis of CVD include imaging studies of the heart and vascular system, as well as imaging studies of other body organs applicable to CVD risk. The American Society for Preventive Cardiology (ASPC) has published “Ten Things to Know About Ten Cardiovascular Disease Risk Factors.” Similarly, this “ASPC Top Ten Imaging” summarizes ten things to know about ten imaging studies related to assessing CVD and CVD risk, listed in tabular form. The ten imaging studies herein include: (1) coronary artery calcium imaging (CAC), (2) coronary computed tomography angiography (CCTA), (3) cardiac ultrasound (echocardiography), (4) nuclear myocardial perfusion imaging (MPI), (5) cardiac magnetic resonance (CMR), (6) cardiac catheterization [with or without intravascular ultrasound (IVUS) or coronary optical coherence tomography (OCT)], (7) dual x-ray absorptiometry (DXA) body composition, (8) hepatic imaging [ultrasound of liver, vibration-controlled transient elastography (VCTE), CT, MRI proton density fat fraction (PDFF), magnetic resonance spectroscopy (MRS)], (9) peripheral artery / endothelial function imaging (e.g., carotid ultrasound, peripheral doppler imaging, ultrasound flow-mediated dilation, other tests of endothelial function and peripheral vascular imaging) and (10) images of other body organs applicable to preventive cardiology (brain, kidney, ovary). Many cardiologists perform cardiovascular-related imaging. Many non-cardiologists perform applicable non-cardiovascular imaging. Cardiologists and non-cardiologists alike may benefit from a working knowledge of imaging studies applicable to the diagnosis and prognosis of CVD and CVD risk – both important in preventive cardiology.

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Section: Imaging Studiesmentioning

confidence: 99%

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

Bays

Khera

Blaha³

et al. 2021

American Journal of Preventive Cardiology

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“…The current Gd chelate-based MRI for stroke has relatively low sensitivity and can cause side effects, such as nephrogenic systemic fibrosis and intracranial gadolinium deposition [ 70 , 107 , 108 , 109 , 110 ]. Therefore, it is urgent to promote new and safer research imaging methods for the diagnosis and analysis of stroke.…”

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Zhou

Zhang

et al. 2021

Molecules

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In the past few decades, brain diseases have taken a heavy toll on human health and social systems. Magnetic resonance imaging (MRI), photoacoustic imaging (PA), computed tomography (CT), and other imaging modes play important roles in disease prevention and treatment. However, the disadvantages of traditional imaging mode, such as long imaging time and large noise, limit the effective diagnosis of diseases, and reduce the precision treatment of diseases. The ever-growing applications of inorganic nanomaterials in biomedicine provide an exciting way to develop novel imaging systems. Moreover, these nanomaterials with special physicochemical characteristics can be modified by surface modification or combined with functional materials to improve targeting in different diseases of the brain to achieve accurate imaging of disease regions. This article reviews the potential applications of different types of inorganic nanomaterials in vivo imaging and in vitro detection of different brain disease models in recent years. In addition, the future trends, opportunities, and disadvantages of inorganic nanomaterials in the application of brain diseases are also discussed. Additionally, recommendations for improving the sensitivity and accuracy of inorganic nanomaterials in screening/diagnosis of brain diseases.

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“…86,87 In the past years, it was shown that persons with normal renal function can also develop NSF when exposed to GBCA, but until the exact pathophysiology of GBCA-induced disease is better understood, alternative gadolinium-free methods should be used whenever possible in advanced CKD. 87,88 Native T1 is a novel noncontrast CMR technique based on the longitudinal recovery time of hydrogen atoms following their excitation. In any given magnetic field strength, every tissue will produce a specific range of values.…”

Section: Ard Iac Mag Ne Ti C Re Sonan Ce (Cmr )mentioning

confidence: 99%

“…In advanced CKD, the usage of gadolinium based contrast agents (GBCA) should be considered individually as it is limited by the risk (<1%) of developing a potentially lethal condition, nephrogenic systemic fibrosis (NSF) . In the past years, it was shown that persons with normal renal function can also develop NSF when exposed to GBCA, but until the exact pathophysiology of GBCA‐induced disease is better understood, alternative gadolinium‐free methods should be used whenever possible in advanced CKD …”

Section: Cardiac Magnetic Resonance (Cmr)mentioning

confidence: 99%

Multi‐modality cardiac imaging in advanced chronic kidney disease

Ureche

Sascău

Țăpoi³

et al. 2019

Echocardiography

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Cardiovascular disease (CVD) is the leading cause of death worldwide and is particularly frequent among those with severe renal impairment. Early diagnosis and therapeutic intervention may help alleviate the burden of cardiovascular complication within this population. In the last years, advances have been made toward developing noninvasive imaging techniques that could offer better insight into the cardiac involvement in end‐stage renal disease (ESRD). Conventional transthoracic echocardiography remains the first‐line investigation used to assess cardiac function, but encompassing in our daily practice, the newer approaches such as speckle‐tracking imaging, cardiac computed tomography, or cardiac magnetic resonance can guide us to a more comprehensive understanding of CVD in ESRD. Given that patients with chronic kidney disease may not present with typical CVD symptoms, the amount of information brought by newer imaging techniques is crucial for an accurate diagnosis, risk stratification, and further management. The purpose of this review is to briefly summarize the specific applications of standard cardiac imaging techniques in patients with ESRD and to offer insight into the novel imaging modalities, highlighting the newest research in this field. By doing so, we aim to identify the most important imaging predictors of clinical outcomes in this population.

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Gadolinium-based contrast agents

Cited by 31 publications

References 28 publications

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Multi‐modality cardiac imaging in advanced chronic kidney disease

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