Gadofosveset-enhanced magnetic resonance venography in patients with venous pathology of the lower limbs – Comparison of diagnostic image quality and inter-rater variability with gadobutrol venography and computed tomography venography

Abstract

Gadofosveset-enhanced magnetic resonance venography in patients with venous pathology of the lower limbs -Comparison of diagnostic image quality and inter-rater variability with gadobutrol venography and computed tomography venography.Åkesson, Michael; Lehti, Leena; Höglund, Peter; Åkeson, Per; Wasselius, Johan General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Abstract PurposeThis study was performed to compare the diagnostic quality of Gadofosveset-enhanced MR venography (MRV) with Gadobutrol-enhanced MRV and CT venography for the deep veins of the lower extremities in patients with iliocaval venous pathology. Materials and MethodsDiagnostic capability and image quality was assessed by two independent readers. Inter-reader variability was analyzed by unweighted and quadratic weighted Cohen's kappa values. ResultsThe diagnostic capability was equal to or higher in the Gadofosveset group for all examined vessel segments compared with both control groups. The image quality score was significantly higher for the Gadofosveset group compared to both control groups.Inter-reader variability, expressed by quadratic weighted Cohen's kappa value (k) showed less variability in the Gadofosveset group compared to the control groups. ConclusionOur results show that Gadofosveset enhanced MRV is a reliable technique in clinical routine practice, with image quality superior to both Gadobutrol enhanced MRV and CT venography.