Gadodiamide as an Alternative Contrast Agent during Angioplasty in Patients with Contraindications to Iodinated Media

Zeller, Thomas; Müller, Christian; Frank, Ulrich; Bürgelin, Karlheinz; Sinn, Lutz; Horn, Barbara; Flügel, Peter; Roskamm, H.

doi:10.1177/152660280200900514

Cited by 27 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In such patients, X‐ray DSA or CT angiography with iodinated contrast agents should be avoided as long as possible to prevent further damage to the kidneys. Some authors have reported using Gd instead of iodinated contrast during interventional procedures, and verified the safety of Gd (2, 18–20). However, the off‐label use of Gd is not universally recommended (21).…”

Section: Discussionmentioning

confidence: 89%

Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium, and creatinine measurements

Zhang

Ersoy

Prince

2006

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To investigate the in vivo effects of gadodiamide (Gd-DTPA-BMA) and gadopentetate dimeglumine (Gd-DTPA) on the laboratory measurements of serum calcium, magnesium, and creatinine. Materials and Methods:Medical records from 1993 to 2004 were reviewed to identify inpatients for whom laboratory data were available regarding serum calcium, creatinine, and magnesium levels before and within one day after gadodiamide and gadopentetate dimeglumine enhanced MRI. Patients who underwent both gadolinium (Gd)-enhanced MRI and iodinated contrast-enhanced examinations on separate days within a six-month period were also identified to compare changes in serum creatinine.Results: Serum creatinine did not increase in 2788 cases following gadopentetate dimeglumine and gadodiamide injection. By comparison, serum creatinine increased from 1.21 to 1.28 mg/dL following iodinated contrast, and there were 20 cases (2.6%) of contrast-induced nephrotoxicity (P Ͻ 0.01). Gadopentetate dimeglumine did not affect serum calcium or magnesium measurements. Following 1157 gadodiamide-enhanced examinations, measured serum calcium spuriously dropped from 8.65 to 8.33 mg/dL (P Ͻ 0.0001) and 34 patients had spurious critical hypocalcemia (Ͻ6 mg/dL). Of 60 patients with high-dose gadodiamide injection and renal insufficiency, 36.7% (N ϭ 22) had spurious critical hypocalcemia immediately post MRI. In 216 patients with renal insufficiency, the mean serum magnesium level increased slightly from 1.69 to 1.77 mEq/L following gadodiamide injection (P Ͻ 0.0001). Conclusion:Gd-based contrast agents are safe for MRI and MR angiography (MRA), and do not induce nephrotoxicity. However, gadodiamide interferes with serum calcium and magnesium measurements-particularly at high doses and/or with renal insufficiency.

show abstract

Section: Discussionmentioning

confidence: 89%

Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium, and creatinine measurements

Zhang

Ersoy

Prince

2006

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Zeller et al examined the use of gadodiamide as the sole contrast agent in patients with iodinated contrast allergy for digital subtraction angiography and angioplasty with or without stent placement [27]. The volume of gadodiamide administered ranged from 60 to 200 mL (mean volume being 136 ± 46 mL).…”

Section: Resultsmentioning

confidence: 99%

Does gadolinium‐based angiography protect against contrast‐induced nephropathy?: A systematic review of the literature

Boyden

Gurm

2008

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…13 Image quality during fluoroscopic studies, though inferior to iodinated contrast agents, is often adequate and successful peripheral and renal artery intervention using gadolinium or related agents has been reported. 5 Caridi et al 4 described renal artery angioplasty in 21 patients using digital subtraction angiography with CO 2 contrast. Six of the patients had allergic contraindications to standard agents, and all interventions were successful.…”

Section: Discussionmentioning

confidence: 99%

“…3 Methods to avoid or minimize contrast usage include adjunctive ultrasound imaging, gadolinium-based contrast, and digital subtraction angiography with CO 2 contrast. [4][5][6] We report a patient with a history of severe, recurrent allergic reactions to iodinated contrast administration and symptomatic central vein stenosis successfully treated with intravascular sonography (IVUS) and pressure gradientdirected percutaneous angioplasty and stenting. No radiographic contrast agent was used during the diagnostic procedure or endovascular intervention.…”

mentioning

confidence: 99%

Intravascular ultrasound‐guided central vein angioplasty and stenting without the use of radiographic contrast agents

Matthews

Jue

2008

J of Clinical Ultrasound

View full text Add to dashboard Cite

Patients with contraindications to iodinated radiographic contrast agents present a significant challenge during endovascular intervention. A 46-year-old man with end-stage renal disease and a normally functioning left upper extremity arteriovenous fistula presented with severe left arm edema. The patient's history included repeated severe anaphylactoid reactions with severe respiratory distress upon exposure to iodinated contrast. In an attempt to avoid the use of iodinated contrast, angioplasty and stent placement of a severe central venous stenosis were performed using only fluoroscopy and intravascular sonography. In patients unable to receive iodinated contrast secondary to anaphylactoid reactions, intravascular sonography can be used to guide angioplasty and stenting of central venous stenosis.

show abstract

Gadodiamide as an Alternative Contrast Agent during Angioplasty in Patients with Contraindications to Iodinated Media

Abstract: For patients with contraindications to iodinated materials, gadodiamide may be a suitable alternative for renal or peripheral DSA followed by angioplasty.

Cited by 27 publications

References 28 publications

Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium, and creatinine measurements

Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium, and creatinine measurements

Does gadolinium‐based angiography protect against contrast‐induced nephropathy?: A systematic review of the literature

Intravascular ultrasound‐guided central vein angioplasty and stenting without the use of radiographic contrast agents

Contact Info

Product

Resources

About