Abstract:Gadd45a is a mediator of growth arrest and its expression is suppressed in primary human MLL-rearranged AML (predominantly MLL-AF9) and AML1-ETO AML with increased FLT3 expression (Valk et al., N Engl J Med 2004; Perugini et al., Leukemia 2009). While Gadd45a is frequently silenced in several human cancers, including leukemia, little is know about how Gadd45a loss contributes to leukemogenesis. Our studies have shown that Gadd45a loss promotes MLL-AF9 mediated development in AML in mice and protects leukemic c… Show more
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