Gabor-domain optical coherence tomography to aid in Mohs resection of basal cell carcinoma

Tankam, Patrice; Soh, Jonathan; Canavesi, Cristina; Lanis, Mara; Hayes, A. B.; Cogliati, Andrea; Rolland, Jannick P.; Ibrahim, Sherrif F.

doi:10.1016/j.jaad.2018.09.029

Cited by 11 publications

(8 citation statements)

References 4 publications

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“…In the meantime, HFUS facilitates the development of teledermatology as it can be used in an asynchronous store and forward manner, giving patients the possibility of being examined, monitored, and managed by a medical expert in a distant location (3). HFUS has some limitations (Table II; [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82]. HFUS is of particular value in the diagnosis and differential diagnosis of skin cancer, especially melanoma.…”

Section: Discussionmentioning

confidence: 99%

Updated Role of High-frequency Ultrasound in Assessing Dermatological Manifestations in Autoimmune Skin Diseases

Chai¹,

Zhu²,

Luo³

et al. 2022

Acta Derm Venereol

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Autoimmune skin diseases are a group of disorders that arise due to the dysregulated immune system attacking self-antigens, causing multiple tissue and organ lesions. With disease progression, the physical and psychological health of patients may be seriously damaged. High-frequency ultrasound is non-invasive, reproducible, and suitable for visualizing the fine structure of external organs. The usage of high-frequency ultrasound has increased in recent years in the auxiliary diagnosis and monitoring of various skin diseases; it serves as a promising tool for dermatological disease assessment. This review summarizes the characteristics of high-frequency ultrasound imaging in common autoimmune skin diseases, including systemic lupus erythematosus, scleroderma, psoriasis, dermatomyositis, and pemphigus/pemphigoid. The objective of this review is to provide new ideas and strategies for dermatologists to diagnose and track the prognosis of autoimmune skin diseases. .

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Section: Discussionmentioning

confidence: 99%

Updated Role of High-frequency Ultrasound in Assessing Dermatological Manifestations in Autoimmune Skin Diseases

Chai¹,

Zhu²,

Luo³

et al. 2022

Acta Derm Venereol

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“…22 Moreover, in 2019, Tankam et al confirmed those evidences using a Gabor-domain OCT, an advanced OCT which provides cellular resolution in crosssectional and en-face images. 24 Differently from dermoscopy and VDS-assisted-MMS, which provided contradictory results, OCT seems to bring a clear improvement in the presurgical evaluation of skin tumors treated with MMS, though the number of studies is limited.…”

Section: Dermoscopy and Videodermoscopymentioning

confidence: 99%

Noninvasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: A review of the literature

Venturi

Pellacani

Farnetani

et al. 2022

Dermatologic Therapy

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Mohs micrographic surgery (MMS) is considered the gold standard treatment for skin cancers. Though the high cure rates it offers, MMS presents some disadvantages, as it is a relatively time-consuming procedure involving several professionals (physicians and technicians). A better definition of tumor margins in the preoperative setting with any optical noninvasive diagnostic method may reduce the numbers of MMS steps and the overall duration of the procedure. The present review was conducted and reported using validated search strategies from the following databases: PUBMED and Ovid MEDLINE. Our review describes the use of procedures such as dermoscopy, optical coherence tomography, reflectance confocal microscopy and fluorescent confocal microscopy to determine tumor extension in the preoperative setting of Mohs surgery for the treatment of skin cancers. Presurgical margin assessment with noninvasive diagnostic techniques seem to provide a benefit in the patients' management, especially for tumors located in critical areas with a high risk of recurrence. The use is limited to the high costs and limited availability of new technologies.

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“…Gabor-Domain Optical Coherence Microscopy GDOCM was first developed for contact imaging, which is preferred in applications that benefit from index-matching between the microscope and the sample, such as dermatology. 27,39,40 The contact imaging modality, however, is not desirable for corneal imaging, since physical contact may cause damage to the tissue, and requires exposing the tissue to the outside environment. The GDOCM microscope was recently redesigned to support two imaging modalities: contact and noncontact with 15-mm working distance.…”

Section: Noncontact 3d Large Field-of-view Corneal Imaging Withmentioning

confidence: 99%

Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells

2020

Self Cite

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. Significance: An accurate, automated, and unbiased cell counting procedure is needed for tissue selection for corneal transplantation. Aim: To improve accuracy and reduce bias in endothelial cell density (ECD) quantification by combining Gabor-domain optical coherence microscopy (GDOCM) for three-dimensional, wide field-of-view ( ) corneal imaging and machine learning for automatic delineation of endothelial cell boundaries. Approach: Human corneas stored in viewing chambers were imaged over a wide field-of-view with GDOCM without contacting the specimens. Numerical methods were applied to compensate for the natural curvature of the cornea and produce an image of the flattened endothelium. A convolutional neural network (CNN) was trained to automatically delineate the cell boundaries using 180 manually annotated images from six corneas. Ten additional corneas were imaged with GDOCM and compared with specular microscopy (SM) to determine performance of the combined GDOCM and CNN to achieve automated endothelial counts relative to current procedural standards. Results: Cells could be imaged over a larger area with GDOCM than SM, and more cells could be delineated via automatic cell segmentation than via manual methods. ECD obtained from automatic cell segmentation of GDOCM images yielded a correlation of 0.94 ( ) with the manual segmentation on the same images, and correlation of 0.91 ( ) with the corresponding manually counted SM results. Conclusions: Automated endothelial cell counting on GDOCM images with large field of view eliminates selection bias and reduces sampling error, which both affect the gold standard of manual counting on SM images.

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Gabor-domain optical coherence tomography to aid in Mohs resection of basal cell carcinoma

Cited by 11 publications

References 4 publications

Updated Role of High-frequency Ultrasound in Assessing Dermatological Manifestations in Autoimmune Skin Diseases

Updated Role of High-frequency Ultrasound in Assessing Dermatological Manifestations in Autoimmune Skin Diseases

Noninvasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: A review of the literature

Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells

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