GABARAP interacts with EGFR — supporting the unique role of this hAtg8 protein during receptor trafficking
Alina Üffing,
Oliver H. Weiergräber,
Melanie Schwarten
et al.
Abstract:The human Atg8 family member GABARAP is involved in numerous autophagy‐related and ‐unrelated processes. We recently observed that specifically the deficiency of GABARAP enhances epidermal growth factor receptor (EGFR) degradation upon ligand stimulation. Here, we report on two putative LC3‐interacting regions (LIRs) within EGFR, the first of which (LIR1) is selected as a GABARAP binding site in silico. Indeed, in vitro interaction studies reveal preferential binding of LIR1 to GABARAP and GABARAPL1. Our X‐ray… Show more
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