Gabapentin versus Lamotrigine Monotherapy: A Double‐blind Comparison in Newly Diagnosed Epilepsy

Brodie, Martin J.; Chadwick, David; Anhut, Henning; Otte, Andreas; Messmer, Silke-Lo; Maton, Stephen; Sauermann, W; Murray, Gordon D.; Garofalo, Elizabeth

doi:10.1046/j.1528-1157.2002.45401.x

Cited by 102 publications

(64 citation statements)

References 21 publications

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“…Two studies have compared LTG and GBP and found little difference. 78,80 They were too short, however, to allow meaningful comparison of efficacy outcomes, so that the treatment failure outcomes reported in the studies were dominated by the drugs' similar and good tolerability.…”

Section: Arm Amentioning

confidence: 99%

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Marson¹,

Appleton²,

Ga³

et al. 2007

Health Technol Assess

102

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HTAHealth Technology Assessment NHS R&D HTA Programme www.hta.ac.uk HTAHow to obtain copies of this and other HTA Programme reports. An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide. Declared competing interests of authors: AG Marson has received speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo and research funding from Pfizer. DW Chadwick has received consultancy fees, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo. DF Smith has received speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo and research funding from Glaxo SmithKline. R Appleton has received consultancy fees, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline and Sanofi Synthelabo. GA Baker has received research funding, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo. A Jacoby has received research funding from Sanofi Synthelabo, GSK and Janssen-Cilag and has acted as a research consultant to Johnson and Johnson Pharmaceuticals. Published October 2007This report shoul...

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Section: Arm Amentioning

confidence: 99%

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Marson¹,

Appleton²,

Ga³

et al. 2007

Health Technol Assess

102

View full text Add to dashboard Cite

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“…This is particularly pertinent if more patients are lost from one treatment group than the other. 64 The majority of studies (93) accounted for all patients and six did not. 43,[65][66][67][68][69] Twelve studies, including eight abstracts, 40,41,[44][45][46][47]59,60 provided insufficient information.…”

mentioning

confidence: 99%

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

Wilby¹,

Kainth²,

Hawkins³

et al. 2005

Health Technol Assess

199

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS, the public...

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“…The majority of AEDs available have demonstrated a similar effi cacy for treating this type of crisis (Mattson et al 1985(Mattson et al , 1992Brodie et al 1999Brodie et al , 2002. Therefore, the choice of drug will fundamentally depend upon its pharmacokinetic profi le and the likelihood of causing secondary effects (Sánchez-Alvarez et al 2005) which, as we have seen, have particular repercussions among the elderly.…”

Section: First Choice Aeds For the Elderlymentioning

confidence: 94%

Management of epilepsy in the elderly

Poza

2008

NDT

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Epilepsy among the elderly is a frequently occurring pathology, differing in etiology, clinical presentation and prognosis from those of young people. In addition, beyond a certain age, physiological modifi cations are produced in the metabolism which alter the pharmacokinetics of antiepileptic drugs (AEDs), increasing the risk of pharmacological interactions, already greater in these patients due to the frequency of poly-pharmacy. Furthermore, elderly patients are particularly sensitive to certain secondary effects of AEDs, as for example, cognitive disturbances, osteoporosis or weight increase. Given that the effi cacy of the major AEDs is a priori quite similar, and that the epilepsies occurring in this age-group generally have a good prognosis, the selection of an AED will depend more upon its pharmacokinetics and ability to induce certain secondary effects than on its effi cacy. In this respect, levetiracetam and pregabalin, followed by oxcarbazepine and lamotrigine have the most favorable pharmocokinetical profi le. Moreover, on the whole these drugs have very few cognitive effects, do not induce osteoporosis and, with the exception of pregabalin, do not affect weight, making them the fi rst selection for use in the treatment of epilepsy in the elderly.

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Gabapentin versus Lamotrigine Monotherapy: A Double‐blind Comparison in Newly Diagnosed Epilepsy

Cited by 102 publications

References 21 publications

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

Management of epilepsy in the elderly

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