Gabapentin premedication for postoperative analgesia and emergence agitation after sevoflurane anesthesiain peadiatric patients.

Abstract

Gabapentin premedication decreases postoperative 24th hour analgesic consumption and attenuates emergence agitation after sevoflurane anesthesia.

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

“…Postoperative analgesia was provided with intramuscular diclofenac sodium and intravenous morphine on demand, they found that preoperative administration of gabapentin reduced the intraoperative anesthetic requirements, blunted the hemodynamic response to intubation, and reduced the postoperative opioid consumption which is compatible with this study [16]. In other study by Akgün et al made a study on 46 healthy children aged 3-12 year old, they found that gabapentin premedication decreases postoperative 24 h analgesic consumption and attenuates emergence agitation after sevoflurane anesthesia which correspondent to this study [17].…”

Paediatric emergence delirium: a comprehensive review and interpretation of the literature

“…Gabapentin given as an oral premedication (15 mg kg À1 ) decreased the severity of EA in healthy children (3-12 yr) after a sevoflurane anaesthetic for adenotonsillectomy. 62 Melatonin Preoperative oral administration of melatonin (0.2 or 0.4 mg kg À1 ), despite it having no effect on preoperative anxiety, has been shown to have greater benefits than midazolam 0.5 mg orally in decreasing incidence of emergence delirium. A dose-dependent effect was found.…”

Analgesic Effects of Sevoflurane and Isoflurane on Elderly Patients with Colon Cancer and Their Influences on Immunity and Postoperative Cognitive Function

“…Colon cancer is a kind of tumor with a high morbidity rate in the elderly, which can be cured only by surgery (1)(2)(3)(4). To reduce the pain of patients during surgery, anesthetics need to be applied, but the cognitive ability will be prone to decline after general anesthesia in clinic, and immune dysfunction and other adverse reactions will be caused (5)(6)(7)(8). In order to avoid and reduce the occurrence of the above adverse reactions, therefore, it is particularly critical to choose anesthetics.…”