Gabapentin in chronic cough

Gibson, Peter G.; Vertigan, Anne E.

doi:10.1016/j.pupt.2015.06.007

Cited by 19 publications

(17 citation statements)

References 34 publications

(41 reference statements)

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“…Gabapentin may have a peripheral antinociceptive effect, and cough resolution by gabapentin also interrupts the self‐perpetuating vicious cycle of reflux‐cough, effectively reducing peripheral sensitisation of cough reflex . Finally, cough hypersensitivity may involve both peripheral and central mechanisms . Therefore, the decrease in cough sensitivity after effective treatment with gabapentin or baclofen may reflect the nature of peripheral and central sensitisation, representing the complicated relation between cough and reflux in patients with refractory gastro‐oesophageal reflux‐induced chronic cough.…”

Section: Discussionmentioning

confidence: 99%

“…The principal purpose of the study was to compare the efficacy between baclofen and gabapentin, rather than to confirm their effectiveness in refractory gastro‐oesophageal reflux‐induced chronic cough. In fact, the usefulness of gabapentin for refractory cough has been fully established while baclofen was also successful in the treatment of refractory gastro‐oesophageal reflux‐induced chronic cough and gastro‐oesophageal reflux disease . Moreover, one can criticise that refractory cough responsive to baclofen or gabapentin might belong to unexplained cough instead of refractory gastro‐oesophageal reflux‐induced chronic cough.…”

Section: Discussionmentioning

confidence: 99%

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Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough

Dong

et al. 2019

Aliment Pharmacol Ther

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Background: Neuromodulators are considered potential therapeutic options for refractory gastro-oesophageal reflux-induced chronic cough. Aim: To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough. Methods: Two hundred and thirty-four patients with suspected refractory gastrooesophageal reflux-induced chronic cough, who failed an 8-week course of omeprazole and domperidone, were recruited into the open-labelled study and randomly assigned to receive either gabapentin (maximum daily dose of 900 mg) or baclofen (maximum daily dose of 60 mg) for 8 weeks as add-on therapy to the previous treatment. The primary end point was the successful rate of cough resolution; and the secondary end-points included cough sensitivity to capsaicin and gastro-oesophageal reflux disease questionnaire score and reported side effects. Results:One hundred and eleven patients in the gabapentin group and 106 in the baclofen group completed the study. The overall success rate for cough resolution was comparable (57.3% vs 53.0%, χ 2 = 0.357, P = 0.550) between the two groups.In parallel, cough sensitivity to capsaicin and gastro-oesophageal reflux disease questionnaire score decreased after treatment with either gabapentin or baclofen.However, gabapentin was associated with less frequent somnolence (20.5% vs 35.0%, χ 2 = 6.156, P = 0.013) and dizziness (11.1% vs 23.9%, χ 2 = 6.654, P = 0.010) than baclofen. Conclusions:Gabapentin and baclofen have similar therapeutic efficacy for suspected refractory gastro-oesophageal reflux-induced chronic cough. However, gabapentin may be preferable because of fewer side effects. Trial Register: http:// www.chictr.org/; No.: ChiCTR-ONC-13003066.Ran Dong and Xianghuai Xu contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough

Dong

et al. 2019

Aliment Pharmacol Ther

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“…The importance of central mechanisms is supported by studies which have shown an improvement in cough frequency and severity when treated with gabapentin, a centrally active drug 32 33. Moreover, Javorkova et al 34 showed that patients with GOR and cough tended to have lower cough thresholds for capsaicin after acid and even after saline infusion compared with patients with GOR but without cough.…”

Section: Discussionmentioning

confidence: 99%

Determinants of reflux-induced chronic cough

Herregods

Pauwels

Jafari

et al. 2017

Gut

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“…It also improves cough related quality of life [45]. Side effects of gabapentin include somnolence and dizziness [46].…”

Section: Cough Hypersensitivity Syndrome (Chs)mentioning

confidence: 99%

Chronic Cough in Adults: Make the Diagnosis and Make a Difference

Kaplan

2019

Pulm Ther

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Chronic cough is common and impactful, frustrating both patients and clinicians. An empirical trial of therapy is often done with inhaled corticosteroids, but this practice should be replaced with attempting to make an accurate diagnosis. The three most common causes are upper airway cough syndrome, asthma, and gastroesophageal reflux disease (GERD), but there are often multiple causes involved. Minimal investigations after history, physical exam, travel history, and drug history include a chest radiograph and spirometry. Empirical trial of therapy with inhaled corticosteroids is reasonable if there is evidence of eosinophilic inflammation. Empiric therapy for GERD may also be reasonable in those with symptoms. Red flags should especially be considered an urgency to make the correct diagnosis.

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Gabapentin in chronic cough

Cited by 19 publications

References 34 publications

Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough

Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough

Determinants of reflux-induced chronic cough

Chronic Cough in Adults: Make the Diagnosis and Make a Difference

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