Gabapentin in Bipolar Disorder

Ryback, Ralph S.; Brodsky, Lewis; Munasifi, Faisal

doi:10.1176/jnp.9.2.301

Cited by 60 publications

(29 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in case 1, 2, and 6, the response seemed to be optimal when gabapentin blood level was above 5 µg/ml, a finding consistent with data reported in young adults. 23 The patients responded fairly rapidly to gabapentin after a therapeutic dose was reached, as has been reported in young adults. 20 The most common side effects associated with gabapentin are sedation, ataxia, fatigue, dizziness, gastrointestinal upset, and irritability.…”

Section: Discussionsupporting

confidence: 66%

Gabapentin in Geriatric Mania

Sethi¹,

Mehta²,

Devanand³

2003

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

There is little available information on anticonvulsant treatment of mania in elderly patients. Seven elderly patients, each in a manic episode, were treated with gabapentin. All 7 patients experienced improvement in manic symptoms, with minimal to no side effects. They received gabapentin in combination with antipsychotic medications, and in 1 case in combination with valproate. Gabapentin appears to be a safe and effective treatment in geriatric mania when combined with antipsychotic medications or valproate. Gabapentin appears to be well tolerated with no major adverse drug interactions or side effects in elderly manic patients. This case series suggests that controlled studies are warranted to examine gabapentin's efficacy and side effects, particularly as an adjunctive medication, in geriatric mania.

show abstract

Section: Discussionsupporting

confidence: 66%

Gabapentin in Geriatric Mania

Sethi¹,

Mehta²,

Devanand³

2003

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

show abstract

“…Gabapentin has been found to have minimal side effects, not significantly different from placebo (133) and also has the advantage of not inducing liver enzymes (1 32). Case reports also suggest it may be efficacious in bipolar disorder (134,135). The most recent AED to be licensed as adjunctive therapy in the United Kingdom is tiagabine (TGB), which acts by blocking the uptake of GABA into neurons and glia.…”

Section: Antiepileptic Medicationsmentioning

confidence: 99%

“…Carbamazepine has been shown to be efficacious as an antidepressant in patients without epilepsy and prophylactic in the control of manic-depressive illness (1 12-114), as have VPA (1 12,114-116), lamotrigine (129)(130)(131) and gabapentin (134,135). Therefore, these AEDs should be used for the treatment of epilepsy in patients with co-existent bipolar disorder and additional therapy with lithium may be avoided.…”

Section: Lithiummentioning

confidence: 99%

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

1999

View full text Add to dashboard Cite

Summary: A history of depression or depressive symptomatology has been reported in up to two-thirds of patients with medically intractable epilepsy, whereas community studies have demonstrated affective disorder only in a quarter of these patients. Depression has been reported peri-and interictally. However, differentiation may be difficult in patients with frequent seizures. Most authors have found no correlation between depression and epilepsy variables. However, complex partial seizures, especially of temporal lobe origin, appear to be etiologic factors, particularly in men with left-sided foci. Depression is also more common in patients treated with polytherapy especially with barbiturates, phenytoin, and vigabatrin. Depression has also been described de novo after temporal lobectomy. Psychosocial factors also play a part, but underlying risk factors (e.g., genetic, endocrine and metabolic) may explain the increased rates of depression in people with epilepsy compared to those with other neurologic and chronic medical conditions. The depression appears to be endogenous. Patients tend to exhibit fewer neurotic traits and more psychotic symptoms such as paranoia, delusions, and persecutory auditory hallucinations. Treatment approaches include psychotherapy, rationalization of antiepileptic drug medication, antidepressant treatment, and ECT. The tricyclic and related antidepressants appear to be epileptogenic, especially in people at high risk (personal or family history of seizures, abnormal pretreatment EEG, brain damage, alcohol or substance abuse/withdrawal and concurrent use of CNS-active medication). Seizures tend to occur early in treatment or after dose increments, especially if rapidly titrated. There is little evidence that the newer antidepressants, e.g., selective serotonin reuptake inhibitors, moclobemide, venlafaxine, or nefazodone are more epileptogenic than placebo.

show abstract

“…In on e retrosp ecti ve st udy of bip ola r pa tie n ts who had fa iled to respond to tradition al mood stabilize rs or d evelop ed intolera ble sid e effects from th es e agents, 92% responded positively to ga ba pe nt in (14) . All other publ ish ed studies, consisting of op en trials whi ch have includ ed ga ba pe nt in bot h as monoth erapy and in addition to other psychotropic m edi cation s, have re ported effect ive improvem ent in th e majority of patients (13,15 ,17 ,18) .…”

Section: Clinical Usementioning

confidence: 99%

“…O f some clini cal significa nce is t he fact th at all stu di es to da te exa mining ga ba pe nt in in th e t reatm ent of bip ola r illness have inclu d ed patients who responded to a dose less t han 900 mg/d (13)(14)(15)(16)(17)(18). In on e study of 28 patient s, th e mean gabapen tin dos e was 539 mg/d ( 15).…”

Section: Dosi Gmentioning

confidence: 99%