Gabapentin for Disruptive Behaviour in an Elderly Demented Patient

Goldenberg, Gregory; Kahaner, Kenneth; Basavaraju, Nerlige G.; Rangu, Srinivas

doi:10.2165/00002512-199813020-00011

Cited by 21 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[17][18][19] Neuroleptics. Previously, neuroleptics were the mainstays for the reduction of problematic behaviors, but because of extrapyramidal symptoms (EPS), the risk of tardive dyskinesia (TD), and cardiovascular effects, newer atypical neuroleptics have been more widely used.…”

Section: P H a R M A C O T H E R A P Ymentioning

confidence: 99%

Behavior problems in demented nursing home residents: A multifaceted approach to assessment and management

Sutor

2002

Compr Ther

View full text Add to dashboard Cite

show abstract

Section: P H a R M A C O T H E R A P Ymentioning

confidence: 99%

Behavior problems in demented nursing home residents: A multifaceted approach to assessment and management

Sutor

2002

Compr Ther

View full text Add to dashboard Cite

show abstract

“…To date, there are only case reports of patients with BPSD treated with gabapentin. [144][145][146][147][148] In an open label prospective series, 12 patients were treated with gabapentin for up to eight weeks with an average dose of 900 mg/day. In this antipsychotic-refractory group of mixed dementias there were no significant changes in behavioral scale scores overall, though two patients were rated as much improved and three as minimally improved.…”

Section: Anticonvulsantsmentioning

confidence: 99%

Recommendations for the Management of Behavioral and Psychological Symptoms of Dementia

Herrmann

2001

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

Suppl. 1 -S96 serious problem that they encountered, rating it more frequently as a serious problem than the memory disturbance itself. The significance of BPSD was recently endorsed by both the United States A l z h e i m e r's A s s o c i a t i o n 6 and the International Psychogeriatric Association 1 as research priorities. The phenomenology and prevalence of BPSD have beenThe behavioral and psychological symptoms of dementia (BPSD) include delusions, hallucinations, misidentifications, agitation, wandering, pacing, restlessness, disinhibition, apathy, negativism, emotional lability, depression, anxiety, sleep disturbance and sexually inappropriate behaviours.1 While not included as diagnostic criteria for dementia by DSM-IV 2 or the NINCDS-ADRDA, 3 behaviours such as paranoia, depression, euphoria and apathy were recognized by Alzheimer in the initial description of the illness that bears his name. 4 Historically, the focus on BPSD began only recently, prompted by an early study by Rabins et al,5 who interviewed caregivers of patients with dementia. While these behaviours were noted in 50-90% of patients, caregivers considered physical aggression the most ABSTRACT: Background: The behavioral and psychological symptoms of dementia (BPSD) are common, serious problems that impair the quality of life for both patient and caregiver. In order to provide recommendations based upon the best available evidence, a qualitative literature review was performed. Methods: A search of the English language medical literature published between 1966 and 2000 was performed. The quality of the studies was assessed by considering the subjects, trial design, analysis and results. Final recommendations were based upon the quality of available evidence. Results: The management of BPSD begins with a thorough assessment to search for underlying causes of behaviour change. Concomitant medical illness should be treated and sensory impairment ameliorated. Nonpharmacological approaches should be instituted prior to medication use. These interventions include music, light, changes in level of stimulation and specific behavioral techniques. Antipsychotics are the best studied pharmacological intervention for agitation and aggression and have demonstrated modest but consistent efficacy. Antidepressants such as trazodone and selective serotonin re-uptake inhibitors, as well as anticonvulsants such as carbamazepine and valproic acid have also demonstrated efficacy. Benzodiazepines can be used for short-term treatment as p.r.n. agents when necessary. Pharmacotherapy must be monitored closely for both effectiveness and side effects, with consideration of medication withdrawal when appropriate. Conclusion: The management of BPSD can significantly improve the quality of life for the patient and caregiver. Their assessment and management are essential components of the treatment of dementia.RÉSUMÉ: Recommandations pour la prise en charge des symptômes comportementaux et psychologiques de la démence. Introduction: L e s symptômes comportementaux et ...

show abstract

“…15,22,23 Other areas of clinical use have been in the treatment of substance abuse disorders [24][25][26][27] and in the treatment of agitation and disruptive behavior in Alzheimer's disease. [24][25][26][27][28][29][30] Lamotrigine is an anticonvulsant approved by the FDA for adjunctive therapy in adults with partial seizures. It is also approved as adjunct therapy in the generalized seizures of LennoxGastaut syndrome in adults and pediatric patients.…”

Section: Psychiatric Uses Of Newer Anticonvulsantsmentioning

confidence: 99%

Psychiatric Uses of Newer Anticonvulsants

Berigan

2001

Prim. Care Companion CNS Disord.

View full text Add to dashboard Cite

Gabapentin for Disruptive Behaviour in an Elderly Demented Patient

Cited by 21 publications

References 7 publications

Behavior problems in demented nursing home residents: A multifaceted approach to assessment and management

Behavior problems in demented nursing home residents: A multifaceted approach to assessment and management

Recommendations for the Management of Behavioral and Psychological Symptoms of Dementia

Psychiatric Uses of Newer Anticonvulsants

Contact Info

Product

Resources

About