“…Third, by conversion of animal doses to human equivalent doses (i.e., rat dose in mg/ kg × 0.16, as recommended by the U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research) (U.S. Department of Health and Human Services, 2005), the doses (25-200 mg/kg) of gabapentin we used in the present study in rats are equivalent to 4-30 mg/kg in humans. This is equivalent to the daily effective doses used for relieving pain (300-1200 mg/day, ≈5-20 mg/kg based on average body weight of 60 kg) (Mathiesen et al, 2007) or for controlling partial seizures (300-1800 mg/day, ≈5-30 mg/kg/day) (Morris, 1999) or for cocaine use (600-2400 mg/day, ≈10-40 mg/kg/day) in other clinical trials (Hart et al, 2004;Myrick et al, 2001;Raby, 2000;Raby and Coomaraswamy, 2004). It may be argued that such direct comparisons between a single animal dose and multiple human doses may be inaccurate or inappropriate.…”