Introduction: Postoperative pain prevention and treatment continues to be a major challenge in postoperative care. Gabapentin has recently become a part of a wide array of postoperative multimodal analgesic regimens. Present study evaluated the efficacy of oral gabapentin in relief of acute post-operative pain in laparoscopic cholecystectomy and also compared the efficacy of oral Gabapentin with that of oral Tramadol. Material and Methods: Sixty ASA I and II physical status patients of both sexes between 20-60 years of age scheduled for elective laparoscopic cholecystectomy were enrolled into this prospective, double blinded, randomized sequential allocation study. Any patient who was unwilling and uncooperative, ASA III and IV physical status, patients having body weight exceeding 20% of ideal body weight, known hypersensitive to any drug, drug or alcohol abuse, pregnant patient, uncontrolled concomitant medical diseases, history of chronic pain conditions, impaired kidney or liver function, laparoscopic cholecystectomy converted to open cholecystectomy, in whom some kind of analgesics were administered within 48 hrs of planned surgery were excluded from the study. Result: Sixty patients (30 males) were enrolled in the study with mean ages of all three groups range from 37.40±9.18 to 41.70±6.84. However the mean age, weight and sex distribution among different groups were statistically insignificant (P>0.05). Mean heart rate in various groups at different intervals were insignificant (p>0.05) in the intra operative period. Among group I, II and III in the postoperative period, changes in mean heart rate was statistically significant (p<0.05). The changes in mean SBP and DBP were statistically insignificant (p>0.05) intraoperatively in the three groups. Conclusion: Premedication with oral 300 mg gabapentin provides better pain relief in the postoperative period as compare to oral 100 mg tramadol and placebo group with minimal side effects.