GABAergic microcircuits in the neostriatum

Tepper, James M.; Koós, Tibor; Wilson, Charles J.

doi:10.1016/j.tins.2004.08.007

Cited by 392 publications

(363 citation statements)

References 48 publications

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“…Accordingly, striatal GABAergic principal neurons, besides inhibiting basal ganglia output nuclei, form functional synapses through their recurrent axon collaterals, establishing a feedback control over striatal neuron activity (Tunstall et al, 2002;Guzman et al, 2003;Koos et al, 2004;Gustafson et al, 2006). Inputs from GABAergic interneurons are another important source of synaptic inhibition of projection neurons, giving rise to a feed-forward inhibitory pathway that is independent of striatal output (Plenz 2003;Tepper et al, 2004;Gustafson et al, 2006). Both the feedback and the feed-forward intrastriatal GABAergic pathways are likely modulated by cannabinoid CB1 receptors and undergo adaptations following wheel running or sucrose consumption.…”

Section: Discussionmentioning

confidence: 99%

Voluntary Exercise and Sucrose Consumption Enhance Cannabinoid CB1 Receptor Sensitivity in the Striatum

Chiara

Errico

Musella

et al. 2009

Neuropsychopharmacol

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The endogenous cannabinoid system is involved in the regulation of the central reward pathway. Running wheel and sucrose consumption have rewarding and reinforcing properties in rodents, and share many neurochemical and behavioral characteristics with drug addiction. In this study, we investigated whether running wheel or sucrose consumption altered the sensitivity of striatal synapses to the activation of cannabinoid CB1 receptors. We found that cannabinoid CB1 receptor-mediated presynaptic control of striatal inhibitory postsynaptic currents was remarkably potentiated after these environmental manipulations. In contrast, the sensitivity of glutamate synapses to CB1 receptor stimulation was unaltered, as well as that of GABA synapses to the stimulation of presynaptic GABAB receptors. The sensitization of cannabinoid CB1 receptor-mediated responses was slowly reversible after the discontinuation of running wheel or sucrose consumption, and was also detectable following the mobilization of endocannabinoids by metabotropic glutamate receptor 5 stimulation. Finally, we found that the upregulation of cannabinoid transmission induced by wheel running or sucrose had a crucial role in the protective effects of these environmental manipulations against the motor and synaptic consequences of stress.

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Section: Discussionmentioning

confidence: 99%

Voluntary Exercise and Sucrose Consumption Enhance Cannabinoid CB1 Receptor Sensitivity in the Striatum

Chiara

Errico

Musella

et al. 2009

Neuropsychopharmacol

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“…The main transmitter in the entire medium spiny projection system is g-amino-butyric acid (GABA), which is known to exert a strong inhibitory effect (Kita et al, 2004;Tepper et al, 2004). Activation of striatopallidal or striatonigral neurons, for example, inhibits neuronal activity in GP or SNr, respectively.…”

Section: Information Outflowmentioning

confidence: 99%

Behavioral Electrophysiology of Psychostimulants

Rebec

2006

Neuropsychopharmacol

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The motor-activating effects of amphetamine and other psychostimulants such as cocaine depend on an increase in dopamine (DA) transmission in the striatum, a key component of the basal ganglia and the forebrain motive circuit. This review focuses on research aimed at using electrophysiological techniquesFincluding extracellular unit recording and iontophoresisFin alert, fully functioning animals to understand how these drugs alter striatal neuronal processing under behaviorally relevant conditions. The data indicate that DA works in conjunction with glutamate (GLU), an excitatory amino acid, to enhance the signal-to-noise ratio of afferent information. This DA-GLU interaction appears to play a critical role in the amphetamine-induced activation of striatal neurons. The pattern of striatal activation, moreover, changes as the behavioral response changes from unfocused locomotion to highly focused, stereotyped behavior, but interestingly, the striatal response pattern is not reflected in substantia nigra reticulata, a primary target of striatal efferents. Although cocaine also activates striatal neurons during behavior, the underlying mechanisms appear to be complicated by factors unique to this drug and deserve further evaluation. Collectively, these findings provide unique insight into the neuronal processes by which the striatum participates in psychostimulant-induced motor behavior.

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“…Numerous functions of the NSt are thought to depend on this inhibition (12,(19)(20)(21)(22), such as the selection and organization of learned motor synergies and contrast enhancement (20)(21)(22)(23)(24)(25). Another form of neostriatal inhibition is due to local circuit fast-spiking (FS) interneurons (13,14,(26)(27)(28)(29)(30)(31)(32). The inhibition from FS interneurons is stronger than that between SPNs (13,14,(26)(27)(28)(29)(30)(31)(32).…”

mentioning

confidence: 99%

“…Another form of neostriatal inhibition is due to local circuit fast-spiking (FS) interneurons (13,14,(26)(27)(28)(29)(30)(31)(32). The inhibition from FS interneurons is stronger than that between SPNs (13,14,(26)(27)(28)(29)(30)(31)(32). But inhibition between SPNs makes the majority of contacts (12,28,32).…”

mentioning

confidence: 99%