GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

The role of GABAergic inhibition in shaping duration selectivity of bat inferior collicular neurons determined with temporally patterned sound trains

“…We have previously suggested that increasing PRR not only enables the bat to obtain as much information as possible about the localized prey from analysis the echoes but also sharpens multi-parametric echo selectivity for accurate prey capture (Jen and Zhou, 1999;Jen et al, 2001Jen et al, , 2002Zhou and Jen, 2002;Wu and Jen, 1996). In the present study, we show that duration selectivity of IC neurons improves and the BD shortens with increasing PRR (Figs.…”

“…Previous studies show that the interplay between these two opposing inputs contributes to auditory temporal processing and shapes multi-parametric selectivity (e.g., duration, frequency, amplitude, direction, etc.) of IC neurons using single repetitive sound pulses or temporally patterned trains of sound pulses (Casseday and Covey, 1995;Casseday et al, 1994Casseday et al, , 2000Jen and Feng, 1999;Jen and Zhang, 2000;Jen et al, 2002;Klug et al, 1995;Koch and Grothe, 1998;LeBeau et al, 1996LeBeau et al, , 2001Lu and Jen, 2001;Lu et al, 1997Lu et al, , 1998Zhou and Jen, 2002).…”

“…When studied with temporally patterned trains of sound pulses at different pulse repetition rates (PRR), the response selectivity of IC neurons in bats has been shown to improve with increasing PRR in multi-parametric domains (Galazyuk et al, 2000;Jen and Zhou, 1999;Jen et al, 2001Jen et al, , 2002Smalling et al, 2001;Jen, 1995a,b, 1996;Zhou and Jen, 2002). In our laboratory, we have previously studied the role of GABAergic inhibition in shaping the frequency and directional selectivity of bat IC neurons with PRR Zhou and Jen, 2002).…”

Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

“…By using temporally patterned sound trains at different RRs, Jen et al have systematically investigated the effects of stimulus RR on frequency, duration, and amplitude domains. Their results indicated that the response selectivity of IC neurons in bats has been shown to improve with increasing PRR in multi-parametric domains Jen et al, 1993Jen et al, , 2002Jen and Feng, 1999;Jen and Zhou, 1999;Wu and Jen, 2006b).…”

The role of GABAergic inhibition in shaping the response size and duration selectivity of bat inferior collicular neurons to sound pulses in rapid sequences

“…Many studies have shown that the interplay between excitation and GABAergic and/or glycinergic inhibition shapes auditory response properties and multi-parametric selectivity of IC neurons (e.g., duration, frequency, amplitude, direction, etc.) (Casseday et al, 1994(Casseday et al, , 2000Fuzessery and Hall, 1996;Jen and Feng, 1999;Jen and Zhang, 2000;Jen and Zhou, 1999;Jen et al, 2001Jen et al, , 2002Klug et al, 1995;Koch and Grothe, 1998;LeBeau et al, 1996LeBeau et al, , 2001Lu and Jen, 2001). Furthermore, two recent studies have shown that inhibitory inputs with stronger intensity and longer duration are more effective in producing inhibition of auditory response of IC neurons than inhibitory inputs with weaker intensity and shorter duration Jen, 2002, 2003).…”