GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro

Hollnagel, Jan‐Oliver; Maslarova, Anna; Haq, Rizwan ul; Heinemann, Uwe

doi:10.1016/j.neulet.2014.04.045

Cited by 17 publications

(17 citation statements)

References 35 publications

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“…Interestingly, modulating phasic and tonic inhibition can affect the incidence of SPW in either direction. Increasing the time constant of GABA A -receptors decreases the incidence of SPW (B€ ahner et al, 2011;Viereckel et al, 2013), while blocking or activating GABA B receptors increases or decreases their occurrence respectively (Ellender et al, 2010;Hollnagel et al, 2014). Surprisingly, however, block of tonic GABA A transmission by low concentrations of gabazine (200 nM) completely abolishes spontaneously occurring SPW-R oscillations in vitro (Ellender et al, 2010).…”

Section: Sharp Wave Ripple Oscillationsmentioning

confidence: 97%

Differential effects of oxytocin on mouse hippocampal oscillations in vitro

Maier

Kaiser

Grinevich

et al. 2016

Eur J of Neuroscience

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The hypothalamic neuropeptide oxytocin (OT) controls childbirth and lactation, is involved in social behaviors, plays a role in various psychiatric disorders, and has effects on learning and memory. Although behavioral effects of OT have been extensively studied, much less is known about its effects on neuronal and network activity patterns. Here, we investigate the effect of OT on two major patterns of hippocampal network activity in mouse hippocampal slices. We studied different in vitro models of gamma-frequency oscillations and sharp wave-ripple complexes (SPW-R), two patterns implicated in spatial memory formation and memory consolidation respectively. Strikingly, we found a profound difference of OT on these distinct, mutually exclusive activity patterns. While gamma oscillations where not affected by the activation of hippocampal OT receptors, SPW-R were potently and rapidly suppressed. Interestingly, the temporal precision of oscillation-coupled spikes was enhanced at the same time. Thus, OT exerts strongly different modulatory effects on different network patterns, most likely by inhibition of different sets of inhibitory interneurons. The observed dichotomy between gamma and SPW-R oscillations may have profound effects on the behavioral and cognitive effects of OT which are relevant to cognitive processes and to psychiatric diseases.

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Section: Sharp Wave Ripple Oscillationsmentioning

confidence: 97%

Differential effects of oxytocin on mouse hippocampal oscillations in vitro

Maier

Kaiser

Grinevich

et al. 2016

Eur J of Neuroscience

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“…While CS' subjective complaint was of fading of memories over days, as documented using our test of verbal recall, there was also evidence, from our demanding measure of visual recognition memory, for subtle impairment of memory over shorter intervals (see Figure 4). Recent evidence from animal studies points to a key role for GABA B signalling in the maintenance and consolidation of memories over delays (Cullen, Dulka, Ortiz, Riccio, & Jasnow, 2014) via mechanisms including sharp waveripples (Hollnagel, Maslarova, Haq, & Heinemann, 2014), immediate-early gene expression (Terunuma et al, 2014) and, possibly, neurogenesis (Giachino et al, 2014). The likelihood that 'recurrent rounds of consolidation-like events' (Bekinschtein et al, 2007, p261) are required to maintain memory traces in the hippocampus predicts a progressive weakening of memories in the presence of an agent, such as baclofen, that reduces the effectiveness of each iteration .…”

Section: The Neural Basis Of Alfmentioning

confidence: 99%

The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain – A detailed case report

Zeman

Hoefeijzers

Milton

et al. 2016

Cortex

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We describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term forgetting, evident over intervals of days and iii) a loss of established autobiographical memories. This pattern of impairment has been reported in patients with temporal lobe epilepsy, in particular the subtype of Transient Epileptic Amnesia. The amnesic episodes and accelerated forgetting remitted on withdrawal of baclofen, while the autobiographical amnesia persisted. This exceptional case highlights the occurrence of 'non-standard' forms of human amnesia, reflecting the biological complexity of memory processes. It suggests a role for GABAB signalling in the modulation of human memory over multiple time-scales and hints at its involvement in 'epileptic amnesia'.Dear Professor Gilboa, Thank you for your comments on our paper, and for the reviews, which we found stimulating and helpful .We were glad that you found the paper 'of great value' overall.We have done as you suggested, resubmitting as a regular manuscript, as we found that dealing with the points raised by the reviewers required some additions to the main text of the paper and to the reference list.We decided to leave the description of the control experiment alluded to in the Results (section 3.3, final sentence) in the Supplementary data, as we felt that its inclusion in the main text of the paper was unnecessary. If you disagree, however, we would of course be happy to move it into the main text.We could supply a version of the paper with all changes 'tracked' if you wish.We hope that you now find the paper acceptable for publication. In these responses, for ease of navigation, we have left the reviewers' original remarks in plain text, have italicised our responses and have highlighted the resulting changes to the text:Reviewer #1: In this manuscript (MS) an interesting case of a 52 year old woman is described who showed a complex symptomatology of memory impairments which were attributed to her treatment with intrathecal baclofen for spasticity. While the paper is well-written in general, I have several concerns and comments, which I am going to outline below.The results are in my eyes not as straight-forward as the authors interpret them. I would therefore recommend that the authors devote some more room to discussing other possible interpretations.a) Although the control participants were matched to CS (the patient) with respect to "age, education and performance on standard psychometric tests" the question is whether baclofen (additionally) affected other functions than memory. In particular one would like to know if it impacted on attention and concentration, motivation (to be tested), mood (depression?), and executive functions. There were no significant differences between CS and control participants on standard measur...

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“…Global modulation of network activity may be locally controlled by substances that are released by individual sets of neurons. These include adenosine, adenosine triphosphate (ATP; Schulz et al, 2012) and probably also some peptides (Decker et al, 2009) and involve spillover of glutamate and GABA from the synaptic cleft thereby mediating volume transmission through high affinity ionotropic and metabotropic receptors (Hollnagel et al, 2014). …”

Section: Role Of Neuromodulators On Theta Gamma Oscillations Sharp mentioning

confidence: 99%

State-dependencies of learning across brain scales

Ritter

Born

Brecht

et al. 2015

Front. Comput. Neurosci.

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Learning is a complex brain function operating on different time scales, from milliseconds to years, which induces enduring changes in brain dynamics. The brain also undergoes continuous “spontaneous” shifts in states, which, amongst others, are characterized by rhythmic activity of various frequencies. Besides the most obvious distinct modes of waking and sleep, wake-associated brain states comprise modulations of vigilance and attention. Recent findings show that certain brain states, particularly during sleep, are essential for learning and memory consolidation. Oscillatory activity plays a crucial role on several spatial scales, for example in plasticity at a synaptic level or in communication across brain areas. However, the underlying mechanisms and computational rules linking brain states and rhythms to learning, though relevant for our understanding of brain function and therapeutic approaches in brain disease, have not yet been elucidated. Here we review known mechanisms of how brain states mediate and modulate learning by their characteristic rhythmic signatures. To understand the critical interplay between brain states, brain rhythms, and learning processes, a wide range of experimental and theoretical work in animal models and human subjects from the single synapse to the large-scale cortical level needs to be integrated. By discussing results from experiments and theoretical approaches, we illuminate new avenues for utilizing neuronal learning mechanisms in developing tools and therapies, e.g., for stroke patients and to devise memory enhancement strategies for the elderly.

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GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro

Cited by 17 publications

References 35 publications

Differential effects of oxytocin on mouse hippocampal oscillations in vitro

Differential effects of oxytocin on mouse hippocampal oscillations in vitro

The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain – A detailed case report

State-dependencies of learning across brain scales

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