GABAA Receptor-Mediated Neurotransmission in the Suprachiasmatic Nucleus

Allen, Charles N.; Klett, Nathan J.; Irwin, Robert P.; Moldavan, M. G.

doi:10.1007/978-3-319-08945-4_8

Cited by 2 publications

(1 citation statement)

References 99 publications

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“…All or nearly all SCN neurons exhibit spontaneous inhibitory postsynaptic potentials (IPSPs) across the circadian cycle suggesting that GABA receptors are found on all SCN neurons (De Jeu and Pennartz, 2002; Jiang et al, 1997a; Strecker et al, 1997; Kim and Dudek, 1992; Kononenko and Dudek, 2004; Kretschmannova et al, 2003; Burgoon and Boulant, 1998). Indeed, GABA is the dominant neurochemical signal within the SCN and it plays a major role in circadian timekeeping (Cardinali and Golombek, 1998; Ehlen et al, 2010; Allen et al, 2014). …”

Section: Suprachiasmatic Nucleus (Scn): Functional Anatomical Anmentioning

confidence: 99%

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Albers

Walton

Gamble

et al. 2017

Frontiers in Neuroendocrinology

133

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Virtually every neuron within the suprachiasmatic nucleus (SCN) communicates via GABAergic signaling. The extracellular levels of GABA within the SCN are determined by a complex interaction of synthesis and transport, as well as synaptic and non-synaptic release. The response to GABA is mediated by GABAA receptors that respond to both phasic and tonic GABA release and that can produce excitatory as well as inhibitory cellular responses. GABA also influences circadian control through the exclusively inhibitory effects of GABAB receptors. Both GABA and neuropeptide signaling occur within the SCN, although the functional consequences of the interactions of these signals are not well understood. This review considers the role of GABA in the circadian pacemaker, in the mechanisms responsible for the generation of circadian rhythms, in the ability of non-photic stimuli to reset the phase of the pacemaker, and in the ability of the day-night cycle to entrain the pacemaker.

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Section: Suprachiasmatic Nucleus (Scn): Functional Anatomical Anmentioning

confidence: 99%

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Albers

Walton

Gamble

et al. 2017

Frontiers in Neuroendocrinology

133

View full text Add to dashboard Cite

show abstract

Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock

et al. 2016

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Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This complexity is prominent in the mammalian suprachiasmatic nucleus (SCN). Here, individual neurons exhibit a remarkable amount of asynchronous behavior and transcriptional heterogeneity. However, SCN neurons are able to generate precisely coordinated synaptic and molecular outputs that synchronize the body to a common circadian cycle by organizing into cellular networks. To understand this emergent cellular network property, it is important to reconcile single-neuron heterogeneity with network organization. In light of recent studies suggesting that transcriptionally heterogeneous cells organize into distinct cellular phenotypes, we characterized the transcriptional, spatial, and functional organization of 352 SCN neurons from mice experiencing phase-shifts in their circadian cycle. Using the community structure detection method and multivariate analytical techniques, we identified previously undescribed neuronal phenotypes that are likely to participate in regulatory networks with known SCN cell types. Based on the newly discovered neuronal phenotypes, we developed a data-driven neuronal network structure in which multiple cell types interact through known synaptic and paracrine signaling mechanisms. These results provide a basis from which to interpret the functional variability of SCN neurons and describe methodologies toward understanding how a population of heterogeneous single cells organizes into cellular networks that underlie tissue-level function.

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GABAA Receptor-Mediated Neurotransmission in the Suprachiasmatic Nucleus

Cited by 2 publications

References 99 publications

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock

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