GABAA Receptor Density Is Not Altered by a Novel Herbal Anxiolytic Treatment

Doron, Ravid; Sever, Avital; Handelsman, Assaf; Toledano, Roni; Franko, Motty; Hirshler, Yafit; Shamir, Alon; Burstein, Or; Rehavi, Moshe

doi:10.1007/s12031-018-1078-2

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…Recent in vivo and in vitro studies demonstrated a notable therapeutic potential of several herbal medications for depression and anxiety, with fewer adverse effects ( Burstein et al, 2017 ; Doron et al, 2018 , 2019 ; Russo et al, 2014 ; Sarris & Kavanagh, 2009 ; Yeung et al, 2014 ). Frequent use of such phytotherapies was observed among individuals with depression or anxiety ( Kessler et al, 2001 ; Pan et al, 2013 ).…”

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confidence: 99%

Patients’ attitudes toward conventional and herbal treatments for depression and anxiety: A cross-sectional Israeli survey

Burstein

Shamir

Abramovitz

et al. 2021

Int J Soc Psychiatry

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Background: As many patients view conventional antidepressants and anxiolytics negatively, it is not surprising that the willingness to apply these treatments is far from ideal, thus posing a critical barrier in promoting an effective and durable treatment. Aim: The present study aimed to explore patients’ attitudes toward conventional and herbal treatments for depression and anxiety, while considering cultural and demographic factors, to further elucidate the antecedes that putatively determine the treatment’s outcome. Methods: During June 2017, a cross-sectional survey was conducted using stratified sampling from a large-scale Israeli volunteer online panel. The final sample included 591 Jewish Israeli adults that reported they were suffering from depression or anxiety. Results: A heterogeneous range of attitudes toward treatment was found: for example, a large group of patients did not utilize prescription medications (39%), a professional consultation (12.9%), or any form of treatment (17.4%). Interestingly, these patients were significantly more likely to support naturally-derived treatments and were less concerned with scientific proof. Further, adverse effects were demonstrated as a prominent factor in the choice of treatment. A higher incidence of adverse effects was associated with an increased willingness to consider an alternative herbal treatment. Noteworthy attitudes were found in orthodox-Jewish individuals, who showed similar consultation rates, but utilized more psychological, rather than pharmacological treatments. Conclusions: It is proposed that patients’ perspectives and cultural backgrounds are needed to be taken into consideration during the clinical assessment and choice of treatment. The findings imply that a particular emphasis should be placed on patients that discard conventional pharmacological options and on distinct cultural aspects. Several recommendations for revising the current policy are advocated to promote more culturally-informed and patient-oriented care.

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Section: Introductionmentioning

confidence: 99%

Patients’ attitudes toward conventional and herbal treatments for depression and anxiety: A cross-sectional Israeli survey

Burstein

Shamir

Abramovitz

et al. 2021

Int J Soc Psychiatry

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Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment

et al. 2019

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Moderation of the transgenerational transference of antenatal stress-induced anxiety

et al. 2021

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Maternal stress has debilitating implications for both mother and child, including increased risk for anxiety. The current COVID-19 pandemic escalates these phenomena, thus, urging the need to further explore and validate feasible therapeutic options. Unlike the protracted nature of clinical studies, animal models could offer swift evidence. Prominent candidates for treatment are selective serotonin reuptake inhibitors (SSRIs) to the mother, that putatively accommodate maternal functioning, and, thereby, also protect the child. However, SSRIs might have deleterious effects. It is important to assess whether SSRIs and other pharmacotherapies can moderate the transference of anxiety by soothing maternal anxiety and to examine the extent of offspring’s exposure to the drugs via lactation. To our knowledge, the possibility that antenatal stress exacerbates lactation-driven exposure to SSRIs has not been tested yet. Thirty ICR-outbred female mice were exposed to stress during gestation and subsequently administered with either the SSRI, escitalopram, or the novel herbal candidate, shan-zha, during lactation. Upon weaning, both dams’ and pups’ anxiety-like behavior and serum escitalopram levels were assessed. The major findings of the current study show that both agents moderated the antenatal stress-induced transgenerational transference of anxiety by ameliorating dams’ anxiety. Interestingly though, pups’ exposure to escitalopram via lactation was exacerbated by antenatal stress. The latter finding provides a significant insight into the mechanism of lactation-driven exposure to xenobiotics and calls for a further consideration vis-à-vis the administration of other drugs during breastfeeding.

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GABAA Receptor Density Is Not Altered by a Novel Herbal Anxiolytic Treatment

Cited by 5 publications

References 58 publications

Patients’ attitudes toward conventional and herbal treatments for depression and anxiety: A cross-sectional Israeli survey

Patients’ attitudes toward conventional and herbal treatments for depression and anxiety: A cross-sectional Israeli survey

Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment

Moderation of the transgenerational transference of antenatal stress-induced anxiety

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