GABA signaling: A route to new pancreatic β cells

Rutter, Guy A.

doi:10.1038/cr.2017.20

Cited by 11 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More importantly, these new β‐like cells were functional and could repeatedly reverse chemically induced diabetes in vivo. Similarly, the treatment of transplanted human islets with GABA resulted in α cell loss and an accompanying increase in β‐like cell count, which also implicated the α‐ to β‐like cell transformation process in humans (Ben‐Othman et al, 2017; Rutter, 2017; Vieira et al, 2017).…”

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 96%

“…Artemisinin is a small molecule that functionally represses Arx by causing its translocation to the cytoplasm (Li et al, 2017). In zebrafish, rodents, and human pancreatic islets, artemisinin's action via protein gephyrin depends on GABA A R signaling mediation for the regeneration of pancreatic β‐cell mass from α cells (Ben‐Othman et al, 2017; Li et al, 2017; Weir and Bonner‐Weir, 2017; Rutter, 2017; Figure 3B). Another study reported that long‐term in vivo GABA administration in mice stimulated a significant upsurge in the number and size of induced islets, which could possibly be because of either the conversion of α cells to β‐like cells or through neogenesis of pancreatic ductal epithelial cells (Ben‐Othman et al, 2017; Weir and Bonner‐Weir, 2017; Figure 3A).…”

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 99%

“…The islet developmental process suggests that Arx is the critical transcription factor for α cell, while Pax4, along with some other transcription factors, determines the β cells' genesis (Rutter, 2017). Li et al (2017) have found the relationship between artemisinin, Arx, Pax4, and gephyrin (the artemisinin drug‐receptor and the critical regulator of GABA signaling) (Figure 3C).…”

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 99%

See 2 more Smart Citations

Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells

Yun-feng

Ghani

et al. 2020

Cell Biology International

View full text Add to dashboard Cite

In vivo regeneration of lost or dysfunctional islet β cells can fulfill the promise of improved therapy for diabetic patients. To achieve this, many mitogenic factors have been attempted, including gamma‐aminobutyric acid (GABA). GABA remarkably affects pancreatic islet cells’ (α cells and β cells) function through paracrine and/or autocrine binding to its membrane receptors on these cells. GABA has also been studied for promoting the transformation of α cells to β cells. Nonetheless, the gimmickry of GABA‐induced α‐cell transformation to β cells has two different perspectives. On the one hand, GABA was found to induce α‐cell transformation to β cells in vivo and insulin‐secreting β‐like cells in vitro. On the other hand, GABA treatment showed that it has no α‐ to β‐cell transformation response. Here, we will summarize the physiological effects of GABA on pancreatic islet β cells with an emphasis on its regenerative effects for transdifferentiation of islet α cells to β cells. We will also critically discuss the controversial results about GABA‐mediated transdifferentiation of α cells to β cells.

show abstract

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 96%

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 99%

Section: α‐ To β‐Cell Transdifferentiation and The Role Of Gaba In Thmentioning

confidence: 99%

See 1 more Smart Citation

Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells

Yun-feng

Ghani

et al. 2020

Cell Biology International

View full text Add to dashboard Cite

show abstract

“…胰岛β细胞分泌的GABA和锌离子也能抑制α细胞功能. 但是最近的研究表明, 长时间GABA刺激能使α细胞向β细胞转分化并促进胰岛β细胞新生, 改善糖代谢, 对胰岛稳态起到非常重要的维持作用 [19] . 因此在α细胞与β细胞环路中, 两种细胞分泌的物质, 分泌的时间和分泌量, 以及两种细胞在胰岛中的位置对胰岛稳态和血糖稳态起到非常重要的作用.…”

Section: 得注意的是在糖尿病发展过程中尤其是1型糖尿病unclassified

Islet cell circuit

Lin¹,

Cheng²,

Wang³

et al. 2018

Sci. Sin.-Vitae

View full text Add to dashboard Cite

“…One of the involved mechanisms may be GABA-mediated conversion of alpha cells to beta cells [137,138]. While the details of the mechanisms involved need to be further investigated, these studies open the intriguing potential to use GABA treatment to re-generate beta cells in T1D [139].…”

Section: Proposed Gabaergic and Glutamatergic Signaling In Type 1 Diamentioning

confidence: 99%

GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets

Hampe¹,

Mitoma²,

Manto³

2018

GABA and Glutamate - New Developments in Neurotransmission Research

View full text Add to dashboard Cite

Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain's overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.

show abstract

GABA signaling: A route to new pancreatic β cells

Cited by 11 publications

References 10 publications

Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells

Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells

Islet cell circuit

GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets

Contact Info

Product

Resources

About