GABA-Induced Intracellular Mg2+ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks

Yamanaka, Ryu; Shindo, Yutaka; Hotta, Kohji; Suzuki, Kôji; Oka, Kotaro

doi:10.1016/j.cub.2018.10.044

Cited by 27 publications

(32 citation statements)

References 50 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the level of gene expression, GABAergic activity has been shown to increase mRNA levels of a chloride transporter that is required for hyperpolarizing IPSPs (Ganguly et al, 2001). One intracellular pathway that could mediate such an effect is the GABA A receptormediated release of Mg 2ϩ from mitochondria, which stimulates both the CREB and mTOR signaling pathways (Yamanaka et al, 2018). Activation of metabotropic GABA B receptors can also induce long-lasting or permanent changes to the developing CNS.…”

Section: Mechanism Of Pharmacological Actionmentioning

confidence: 99%

Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception

Mowery¹,

Caras²,

Hassan³

et al. 2019

J. Neurosci.

View full text Add to dashboard Cite

Transient periods of childhood hearing loss can induce deficits in aural communication that persist long after auditory thresholds have returned to normal, reflecting long-lasting impairments to the auditory CNS. Here, we asked whether these behavioral deficits could be reversed by treating one of the central impairments: reduction of inhibitory strength. Male and female gerbils received bilateral earplugs to induce a mild, reversible hearing loss during the critical period of auditory cortex development. After earplug removal and the return of normal auditory thresholds, we trained and tested animals on an amplitude modulation detection task. Transient developmental hearing loss induced both learning and perceptual deficits, which were entirely corrected by treatment with a selective GABA reuptake inhibitor (SGRI). To explore the mechanistic basis for these behavioral findings, we recorded the amplitudes of GABA A and GABA B receptor-mediated IPSPs in auditory cortical and thalamic brain slices. In hearing loss-reared animals, cortical IPSP amplitudes were significantly reduced within a few days of hearing loss onset, and this reduction persisted into adulthood. SGRI treatment during the critical period prevented the hearing loss-induced reduction of IPSP amplitudes; but when administered after the critical period, it only restored GABA B receptor-mediated IPSP amplitudes. These effects were driven, in part, by the ability of SGRI to upregulate ␣1 subunitdependent GABA A responses. Similarly, SGRI prevented the hearing loss-induced reduction of GABA A and GABA B IPSPs in the ventral nucleus of the medial geniculate body. Thus, by maintaining, or subsequently rescuing, GABAergic transmission in the central auditory thalamocortical pathway, some perceptual and cognitive deficits induced by developmental hearing loss can be prevented.

show abstract

Section: Mechanism Of Pharmacological Actionmentioning

confidence: 99%

Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception

Mowery¹,

Caras²,

Hassan³

et al. 2019

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…A very interesting study on the effects of magnesium signaling on the structural and functional development of neuronal cells has been carried out by Yamanaka et al [ 63 ]. It was shown that the activation of gamma-aminobutyric acid A (GABA A ) receptors mediates the GABA-induced cytosolic [Mg] 2+ increase in immature neurons independently of calcium signals.…”

Section: Magnesiummentioning

confidence: 99%

“…It was shown that the activation of gamma-aminobutyric acid A (GABA A ) receptors mediates the GABA-induced cytosolic [Mg] 2+ increase in immature neurons independently of calcium signals. Moreover, cytosolic magnesium regulates the signaling activities of extracellular signal-regulated kinase (ERK) negatively, cyclic AMP response element binding protein (CREB) positively, and mammalian target of rapamycin (mTOR) sigmoidally [ 63 ]. As these intracellular signaling pathways regulate neuronal growth and differentiation, magnesium, by activating CREB and mTOR signaling, enhances the maturation of neural networks [ 64 ].…”

Section: Magnesiummentioning

confidence: 99%

General Aspects of Metal Ions as Signaling Agents in Health and Disease

et al. 2020

View full text Add to dashboard Cite

This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions. The first section is devoted to the recent discoveries on magnesium and calcium-dependent signal transduction—the most recognized signaling agents among metals. The following sections then describe signaling pathways where zinc, copper, and iron play a key role. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also involved in a recently discovered type of programmed cell death, ferroptosis. The important differences in metal ion signaling, and its disease-leading alterations, are also discussed.

show abstract

“…One such enzyme is the mammalian target of rapamycin (mTOR) kinase, an important sensor and regulator of cellular energy levels and expenditure [12]. mTOR has a fairly weak affinity for Mg,ATP (K M > 1 mM) compared with most kinases ( [13]. GABA is one of the major inhibitory neurotransmitters of the central nervous system.…”

mentioning

confidence: 99%

“…Using targeted fluorescent indicators for Mg 2+ , Yamanaka et al [13] showed that GABA stimulation elicits a sustained release of Mg 2+ from the mitochondria. Selective activation of inotropic GABA A receptors, but not GABA B , recapitulated the effects of GABA stimulation on [Mg 2+ ] cyto , suggesting that these channel activities directly stimulate Mg 2+ mobilization.…”

mentioning

confidence: 99%