GABA, a natural immunomodulator of T lymphocytes

Bjurstöm, Helen; Wang, Jun-Yang; Ericsson, Ida; Bengtsson, Martin; Liu, Yawei; Kumar-Mendu, Suresh; Issazadeh‐Navikas, Shohreh; Birnir, Bryndis

doi:10.1016/j.jneuroim.2008.08.017

Cited by 162 publications

(158 citation statements)

References 32 publications

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“… X  or  X , with varying functional and pharmacological properties. In addition, 1 and 2 may form homomeric channels and are potentially associated with naïve T cells (Bjurstom et al, 2008). In the lymphocytes the GABA A channels may be located at or outside the immunological synapse.…”

Section: Physiological Concentrations Of Gaba Activate Channelsmentioning

confidence: 99%

“…In the islet, GABA may be involved in paracrine mechanisms where GABA secreted by the  cells activates GABA A channels on the glucagon secreting  cells (Rorsman et al, 1989). Another potential role of GABA is inhibition of lymphocytes Bjurstom et al, 2008;Tian et al, 2004). The high-affinity GABA A channels on the lymphocytes are activated by GABA concentrations present around the  cells and thus activated lymphocytes will be inhibited when within the islets.…”

Section: Physiological Concentrations Of Gaba Activate Channelsmentioning

confidence: 99%

“…Neurotransmitters are not only effector molecules in the nervous system but are also emerging as modulators of the immune system where they may modulate the function of immune cells such as lymphocytes (Bjurstom et al, 2008). In recent years reports have emerged indicating that immune cells may express GABA A channels but what physiological role they have is not clear (Alam et al, 2006;Bhat et al, 2010;Bjurstom et al, 2008;ReyesGarcia et al, 2007;Tian et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years reports have emerged indicating that immune cells may express GABA A channels but what physiological role they have is not clear (Alam et al, 2006;Bhat et al, 2010;Bjurstom et al, 2008;ReyesGarcia et al, 2007;Tian et al, 2004). Lenmark and colleagues (Michalkiewicz et al, 2004) have generated congenic Biobreeding (BB) rats that develop spontaneously type 1 diabetes (DR lyp/lyp ) and on the same genetic background BB rats that are diabetes resistant (DR +/+ ).…”

Section: Introductionmentioning

confidence: 99%

“…Pancreatic  cells and some blood cells express GABA A channels (Gladkevich et al, 2006;Olsen and Sieghart, 2008). In T lymphocytes it is known that neurotransmitters´ receptors can be regulated by the T cell receptor activation, cytokines or the neurotransmitters themselves (Bjurstom et al, 2008; have in normal T cell function and disease. The GABA A channels are heteropentamers and to-date 19 GABA A channel subunits have been cloned (Birnir and Korpi, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates

Mendu

Åkesson

Jin

et al. 2011

Molecular Immunology

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Section: Physiological Concentrations Of Gaba Activate Channelsmentioning

confidence: 99%

Section: Physiological Concentrations Of Gaba Activate Channelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates

Mendu

Åkesson

Jin

et al. 2011

Molecular Immunology

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Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics

2011

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I hypothesize here that the ability of probiotics to synthesize neuroactive compounds provides a unifying microbial endocrinology-based mechanism to explain the hitherto incompletely understood action of commensal microbiota that affect the host's gastrointestinal and psychological health. Once ingested, probiotics enter an interactive environment encompassing microbiological, immunological, and neurophysiological components. By utilizing a trans-disciplinary framework known as microbial endocrinology, mechanisms that would otherwise not be considered become apparent since any candidate would need to be shared among all three components. The range of neurochemicals produced by probiotics includes neurochemicals for which receptor-based targets on immune and neuronal elements (intestinal and extra-intestinal) have been well characterized. Production of neurochemicals by probiotics therefore allows for their consideration as delivery vehicles for neuroactive compounds. This unifying microbial endocrinology-based hypothesis, which may facilitate the selection and design of probiotics for clinical use, also highlights the largely unrecognized role of neuroscience in understanding how microbes may influence health.

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Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat

Caride

Fernández-Pérez

Cabaleiro

et al. 2009

J of Applied Toxicology

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The present study was conducted to investigate the possible effects of cadmium exposure on the daily pattern of aspartate, glutamate, glutamine, gamma-aminobutyric acid (GABA) and taurine levels in the mediobasal hypothalamus of adult male rats. For this purpose, animals were treated with cadmium at two different exposure doses (25 and 50 mg l(-1) of cadmium chloride, CdCl(2)) in the drinking water for 30 days. Control age-matched rats received CdCl(2)-free water. After the treatment, rats were killed at six different time intervals throughout a 24 h cycle. CdCl(2) exposure modified the amino acid daily pattern, as it decreased aspartate, glutamate, GABA and taurine levels at 12:00 h with both exposure doses employed. In addition, the treatment with 25 mg l(-1) of CdCl(2) induced the appearance of minimal values at 16:00 h and maximal values between 04:00 and 08:00 h for glutamate, and a peak of glutamine content at 20:00 h. The heavy metal also decreased GABA medium levels around the clock in the mediobasal hypothalamus. However, CdCl(2) did not alter the metabolic correlation between glutamate, aspartate, glutamine and GABA observed in control animals. These results suggest that CdCl(2) induced several alterations in aspartate, glutamate, glutamine, GABA and taurine daily pattern in the mediobasal hypothalamus and those changes may be related to alterations in hypothalamic function.

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GABA, a natural immunomodulator of T lymphocytes

Cited by 162 publications

References 32 publications

Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates

Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics

Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat

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