G6PD deficiency—does it alter the course of COVID-19 infections?

Au, Tsz Yuen; Wiśniewski, Oskar Wojciech; Benjamin, Shamiram; Kubicki, Tadeusz; Dytfeld, Dominik; Gil, Lidia

doi:10.1007/s00277-023-05164-y

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…These findings highlight key homeostatic mechanisms in our cohort that are lung protective and that continue to occur even 3 months from the initial infection. 63 , 64 , 65 …”

Section: Discussionmentioning

confidence: 99%

Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19

Kanth,

Huapaya,

Gairhe

et al. 2024

Cell Reports Medicine

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“…These findings highlight key homeostatic mechanisms in our cohort that are lung protective and that continue to occur even 3 months from the initial infection. 63 , 64 , 65 …”

Section: Discussionmentioning

confidence: 99%

Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19

Kanth,

Huapaya,

Gairhe

et al. 2024

Cell Reports Medicine

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“…Additionally, worsened prognoses and more severe complications of infection may present in type I G6PD-deficient individuals ( 11 ). Viral infection can trigger the body’s pro-oxidant (PO) response, producing ROS to attack pathogens, a normal innate defense mechanism.…”

Section: Discussionmentioning

confidence: 99%

A rare adverse effects of COVID-19 vaccine in a patient with a latent tumor: A case report and literature review

Xu,

Nian

2023

Front. Oncol.

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The 2019 novel coronavirus infection has done significant damage to the world. The effectiveness and safety of the vaccine, the most critical measure to control the epidemic, has attracted attention. In this case, we report the diagnosis and treatment of a rare patient with adverse effects of the COVID-19 vaccine who had G6PD deficiency by genetic tests. We discuss the possible impact of G6PD deficiency on COVID-19 infection and potential vaccine adverse effects. Patients with severe G6PD deficiency should be monitored for vaccine safety. This article may complement a rare mechanism of vaccine side effects and chemotherapy-related side effects.

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The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production

Fuentes-Lemus,

Reyes,

Figueroa

et al. 2023

Biochemical Society Transactions

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The pentose phosphate pathway (PPP) is a key metabolic pathway. The oxidative phase of this process involves three reactions catalyzed by glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL) and 6-phosphogluconate dehydrogenase (6PGDH) enzymes. The first and third steps (catalyzed by G6PDH and 6PGDH, respectively) are responsible for generating reduced nicotinamide adenine dinucleotide phosphate (NAPDH), a key cofactor for maintaining the reducing power of cells and detoxification of both endogenous and exogenous oxidants and electrophiles. Despite the importance of these enzymes, little attention has been paid to the fact that these proteins are targets of oxidants. In response to oxidative stimuli metabolic pathways are modulated, with the PPP often up-regulated in order to enhance or maintain the reductive capacity of cells. Under such circumstances, oxidation and inactivation of the PPP enzymes could be detrimental. Damage to the PPP enzymes may result in a downward spiral, as depending on the extent and sites of modification, these alterations may result in a loss of enzymatic activity and therefore increased oxidative damage due to NADPH depletion. In recent years, it has become evident that the three enzymes of the oxidative phase of the PPP have different susceptibilities to inactivation on exposure to different oxidants. In this review, we discuss existing knowledge on the role that these enzymes play in the metabolism of cells, and their susceptibility to oxidation and inactivation with special emphasis on NADPH production. Perspectives on achieving a better understanding of the molecular basis of the oxidation these enzymes within cellular environments are given.

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G6PD deficiency—does it alter the course of COVID-19 infections?

Cited by 3 publications

References 70 publications

Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19

Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19

A rare adverse effects of COVID-19 vaccine in a patient with a latent tumor: A case report and literature review

The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production

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