Clear-cell syringomas, a rare histologic variant of syringomas, frequently coexist with diabetes mellitus. Clinically, it presents as skin colored papules distributed symmetrically around periorbital region. However, asymmetrical distribution of syringomas is rare and much rarer is the ulceration in such syringomas. Ulceration in such asymmetrical syringomas has not been reported so far. Herein, we report ulceration of clear-cell syringomas involving left groin in a middle aged non-diabetic woman.