G2-S16 dendrimer microbicide does not interfere with the vaginal immune system

Martín-Moreno, Alba; Sepúlveda‐Crespo, Daniel; Serramía-Lobera, M. Jesús; Perisé-Barrios, Ana Judith; Muñoz‐Fernández, María Ángeles

doi:10.1186/s12951-019-0496-9

Cited by 8 publications

(11 citation statements)

References 47 publications

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“…98 No vaginal irritation was detected in BALB/c mice and female rabbits after various consecutive applications for different times with 3% G2-S16. 99 Daily treatment with G2-S16 either, by vaginal topical application or intravenous injection, does not modify the hemogram after 7 or 14 days of treatment. Interestingly enough, G2-S16 dendrimer does not interfere with the vaginal immune system.…”

Section: Nanocarriers or Drugsmentioning

confidence: 94%

Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis

et al. 2020

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Section: Nanocarriers or Drugsmentioning

confidence: 94%

Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis

et al. 2020

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“…Moreover, we performed several assays to investigate the impact of G2-S16 PCD in the vagina immune system. Our results demonstrated the biosafety of this G2-S16 PCD microbicide, as it did not modify the normal activity of the main immune system cells [ 75 ].…”

Section: How Does G2-s16 Pcd Work In Vitro?mentioning

confidence: 84%

“…In vitro G2-S16 PCD dendrimer microbicide does not interfere with the vaginal immune system. [75] 2020…”

mentioning

confidence: 99%

Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials

Relaño-Rodríguez

Muñoz‐Fernández

2020

IJMS

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Development of new, safe, and effective microbicides to prevent human immunodeficiency virus HIV sexual transmission is needed. Unfortunately, most microbicides proved ineffective to prevent the risk of HIV-infection in clinical trials. We are working with G2-S16 polyanionic carbosilane dendrimer (PCD) as a new possible vaginal topical microbicide, based on its short reaction times, wide availability, high reproducibility, and quantitative yields of reaction. G2-S16 PCD exerts anti-HIV activity at an early stage of viral replication, by blocking gp120/CD4/CCR5 interaction, and providing a barrier against infection for long periods of time. G2-S16 PCD was stable at different pH values, as well as in the presence of seminal fluids. It maintained the anti-HIV activity against R5/X4 HIV over time, did not generate any type of drug resistance, and retained the anti-HIV effect when exposed to semen-enhanced viral infection. Importantly, G2-S16 PCD did not modify vaginal microbiota neither in vitro or in vivo. Histopathological examination did not show vaginal irritation, inflammation, lesions, or damage in the vaginal mucosa, after administration of G2-S16 PCD at different concentrations and times in female mice and rabbit animal models. Based on these promising data, G2-S16 PCD could become a good, safe, and readily available candidate to use as a topical vaginal microbicide against HIV.

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“…In addition to its unquestionable microbicidal effect, it has demonstrated in vivo biocompatibility. Recent studies showed that G2-S16 dendrimer does not cause irritation or inflammation in the vaginal epithelium and does not alter the natural immunity of the vagina, which strongly supports the biosafety of this dendrimer for vaginal application to control viral transmission [ 60 , 61 , 62 ].…”

Section: Nanotechnology Approaches For Prevention Of Hiv Infectionmentioning

confidence: 89%

Nanosystems Applied to HIV Infection: Prevention and Treatments

Macchione

Bedoya

Figueroa

et al. 2020

IJMS

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Sexually-transmitted infections (STIs) are a global health concern worldwide as they cause acute diseases, infertility, and significant mortality. Among the bacterial, viral, and parasitic pathogens that can be sexually transmitted, human immunodeficiency virus (HIV) has caused one of the most important pandemic diseases, which is acquired immune deficiency syndrome (AIDS). 32.7 million people have died from AIDS-related illnesses since the start of the epidemic. Moreover, in 2019, 38 million people were living with HIV worldwide. The need to deal with this viral infection becomes more obvious, because it represents not only a problem for public health, but also a substantial economic problem. In this context, it is necessary to focus efforts on developing methods for prevention, detection and treatment of HIV infections that significantly reduce the number of newly infected people and provide a better quality of life for patients. For several decades, biomedical research has been developed allowing quick solutions through the contribution of effective tools. One of them is the use of polymers as vehicles, drug carrier agents, or as macromolecular prodrugs. Moreover, nanosystems (NSs) play an especially important role in the diagnosis, prevention, and therapy against HIV infection. The purpose of this work is to review recent research into diverse NSs as potential candidates for prevention and treatment of HIV infection. Firstly, this review highlights the advantages of using nanosized structures for these medical applications. Furthermore, we provide an overview of different types of NSs used for preventing or combating HIV infection. Then, we briefly evaluate the most recent developments associated with prevention and treatment alternatives. Additionally, the implications of using different NSs are also addressed.

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G2-S16 dendrimer microbicide does not interfere with the vaginal immune system

Cited by 8 publications

References 47 publications

Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis

Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis

Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials

Nanosystems Applied to HIV Infection: Prevention and Treatments

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