Abstract:AimsSickle cell disease is the most common inherited disorder in African and Caribbean populations. Restrictive lung function abnormalities become increasingly common in older patients and indeed are characteristic of sickle chronic lung disease. Young children with SCD, however, frequently have obstructive lung function abnormalities. It is not clear whether the obstructive abnormalities are due to asthma or the elevated pulmonary capillary blood volume seen in SCD children because of their chronic anaemia. S… Show more
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