G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model

Abstract

In the last decades, the strong increase in the proportion of older people worldwide, and the increased prevalence of age associated degenerative diseases, have put a stronger focus on aging biology. In spite of important progresses in our understanding of the aging process, an integrative view is still lacking and there is still need for efficient anti-aging interventions that could improve healthspan, reduce incidence of age-related disease and, eventually, increase the lifespan. Interestingly, some compounds from traditional medicine have been found to possess anti-oxidative and anti-inflammatory properties, suggesting that they could play a role as antiaging compounds, although in depth in vivo investigations are still scarce. In this study we used one the major aging model organisms, Drosophila melanogaster, to investigate the ability of four herb extracts (HEs: Dendrobium candidum, Ophiopogon japonicum, Ganoderma sinense and Panax notoginseng) widely used in traditional Chinese medicine (TCM) to slow down aging and improve healthspan of aged animals. Combining multiple approaches (stress resistance assays, lifespan and metabolic measurements, functional heart characterizations and behavioral assays), we show that these four HEs provide in vivo protection from various insults, albeit with significant compound-specific differences. Importantly, extracts of P. notoginseng and G. sinense increase the healthspan of aging animals, as shown by increased activity during aging and improved heart function. In addition, these two compounds also provide protection in a Drosophila model of Huntington's disease (HD), suggesting that, besides their anti-aging properties in normal individuals, they could be also efficient in the protection against age-related diseases.

Preventive effect and safety of Chinese herbal medicine for oral mucositis during radiotherapy in patients with head and neck cancer: Study protocol for a randomized trial

“…Ophiopogonis has been reported to stimulate lymphocyte proliferation in vitro [ 28 ]. Both are used for the benefit of qi and to promote body fluid production, according to TCM theory, and they are also reported to have the effects of cardiovascular protection, anti-inflammation and anti-cancer [ 27 , 29 , 30 ]. Although in vitro and in vivo studies have provided evidence supporting the purported effects of these ingredients of ZYLGS, we still perceive a need for a clinical trial to assess the efficacy of CHM formula in treating RT-induced OM.…”

Optimization of mycelial growth and cultivation of wild Ganoderma sinense

“…Similar to other species of the genus Ganoderma , G. sinense is used as herbal medicine and health supplement. It has been reported to have antitumor (Han et al, 2021 ), antiaging (Teseo et al, 2021 ), anti-inflammatory (Mei et al, 2019 ), and anticancer (Zheng et al, 2018 ) activities and nitric oxide inhibitory properties (Wang et al, 2020 ). Polysaccharides are the major biological components of G. sinense (Y. Zhang et al, 2019 ).…”

Study of the suitable climate factors and geographical origins traceability of Panax notoginseng based on correlation analysis and spectral images combined with machine learning

“…It is especially suitable for patients with hypertension, hyperlipidemia, hyperglycemia, heart and cerebrovascular diseases, and patients who have low immunity, anemia, and are prone to falling and sprains ( Hawthorne et al., 2022 ; Jiang et al., 2022 ; Zheng et al., 2022 ). Additionally, it improves blood circulation, moisturizes the skin, and slows down aging ( Peng et al., 2017 ; Teseo et al., 2021 ). Phytochemical and pharmacological studies of P. notoginseng have demonstrated that its main biologically active components are dammarane-type saponins consisting of protopanaxadiol and protopanaxatriol glycosides ( Qiao et al., 2018 ; Marianela et al., 2021 ).…”