G-Quartet Oligonucleotides

Ning, Jianguo; Li, Yidong; Xiong, W.; Sha, Wei; Jing, Ling; Tweardy, David J.

doi:10.1158/0008-5472.can-03-4041

Cited by 125 publications

(70 citation statements)

References 44 publications

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“…However, in contrast to Stat3, StatlI has a anti-proliferative and anti-apoptotic effects of Statl1 intact. ODNs are released into the cytoplasm, they form Gcells [69], and are consistent with the results of our docking quartet structures induced by the high concentration of studies.…”

Section: T40215supporting

confidence: 90%

“…formed by T40216 occurred within this region, and that T40214 had the highest percentage of H-bonds formed in The strategy for rational design of GQ-ODNs as inhibithis region with 35% [69]. The percentage of H-bonds tors of Stat3 activity employed in our laboratory (Fig.…”

Section: Strategy Of Rational Drug Design For Gq-odnmentioning

confidence: 91%

“…The results of CD and binding within the critical site of Stat3 and the IC 50 of non-denatured gels showed that T40214 with two G-Cinhibition of Stat3 DNA binding activity (Fig. 2C), success-G-C loops and T40212 with one G-T-G-T loop on top fully establishing a SAR between GQ-ODNs and the Stat3 and one G-C-G-C loop on the bottom formed the same dimer [69]. The linear correlation indicates that the higher G-quartet structures as that of T30923 [71].…”

Section: _50mentioning

confidence: 93%

“…Based upon the molecular model, a structure-activity technology that uses computational approaches to design or relationship of GQ-ODN inhibitors was developed [69]. In identify new agents for cancer therapy.…”

Section: Inhibitors For Cancer Therapymentioning

confidence: 99%

“…Importantly, fluorescence of Bcl-2 and Bcl-XL protein levels. Bcl-2 and Bcl-XL, which was readily detected within tumor xenografts isolated from have ion channel activity, have been reported to inhibit nude mice [69], indicating that GQ-ODN enter their cancer release of cytochrome C from mitochondria [80,81]. Blockcell targets when administered intravenously with PEI.…”

Section: T40215mentioning

confidence: 99%

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Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Ning¹

2005

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and AUTHOR(S)Naijie Jing, Ph.D. PERFORMING ORGANIZA TION NAME(S) AND ADDRESS(ES)8 ABSTRACT (Maximum 200 Words)This annual report is composed of (1) introduction of the goal of this project and specific aims, (2) body of research accomplishments in PI's group from 4/1/04 to 3/31/05, (3) reportable outcomes, and (4) conclusion of researches from 4/1/04 to 3/31/05. The report demonstrated that during the period from 4/1/04 to 3/31/05, PI group made a significant progress in developing a novel and potent anti-cancer agent, which holds promise for the systemic treatment of prostate cancer. Our goal is to develop a novel, potent inhibitor of Stat3 as a therapeutic drug for prostate cancer therapy. In the year 2003, carcinoma of the prostate accounted for an estimated 220,900 new cancer cases and 28,900 deaths, including 30,200 deaths in the United States. Prostate cancer is one of the most frequently diagnosed cancers and the second leading cause of cancer death in American men. Current treatments for androgen-independent prostate cancer have not shown a definitive increase in survival. The treatment options employed for patients with advanced and metastatic prostate cancer are limited. Mounting evidence demonstrates that Stat3 is a critical mediator of oncogenic signaling (1-3) and is active in 82% of prostate cancers (4), 69% of breast cancers (5), 90% of head and neck cancers (HNSCC) (6), 71% of nasopharygeal carcinoma (7) as well as in many other cancers. However, drugs targeting Stat3 have not been used to treat prostate cancer. We propose a novel strategy to inhibit Stat3, which could be very useful in development of prostate cancer therapy, and have developed a G-quartet oligodeoxynucleotide (GQ-ODN), T40214, as a lead compound that preferentially inhibits the DNA-binding activity of Stat3 among STAT protein members such as Statl, resulting in the suppression of Stat3-regulated genes, bcl-x and Mcl-1, in cancer cells (8). We also have constructed a model of GQ-ODN binding onto Stat3 homodimer for rational drug design. The molecular model suggests that the GQ-ODN insert between the two SH2 domains of Stat3 dimer resulting in their destabilization. We further show that T40214 and its derivative T40231 have dramatic in vivo effects on prostate cancer growth in nude mice when given by intravenous or intraperitoneal injections, dramatically retarding tumor growth and significantly increase the length of survival time (Appendices 1...

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Section: T40215supporting

confidence: 90%

Section: Strategy Of Rational Drug Design For Gq-odnmentioning

confidence: 91%

Section: _50mentioning

confidence: 93%

Section: Inhibitors For Cancer Therapymentioning

confidence: 99%

Section: T40215mentioning

confidence: 99%

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Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Ning¹

2005

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Materials Science and Nanotechnology of Nucleic Acids

2021

Chemistry and Biology of Non‐Canonical Nucleic Acids

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Rapid synthesis of BaMoO₄:Eu³⁺ red phosphors using microwave irradiation

Cheng

Wang

et al. 2023

Luminescence

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This study synthesized BaMoO4:Eu 3+ red phosphors using the microwave method.In addition, the phase composition, morphology, and luminescence properties of the red phosphors were characterized using X-ray diffraction, field-scanning electron microscopy, and photoluminescence spectroscopy. The results revealed that doping red phosphors with different concentrations of Eu 3+ does not change the crystal structure of the matrix material. The BaMoO 4 :Eu 3+ phosphors exhibited micron-scale irregular polyhedra, which could be excited by ultraviolet light with a wavelength of 395 nm to induce red-light emission. The optimal dosage of Eu 3+ was 0.08, and the chromaticity coordinates of BaMoO 4 :0.08Eu 3+ phosphors were (0.5869, 0.3099).White light-emitting diode (w-LED) devices manufactured by using a combination of BaMoO 4 :0.08Eu 3+ phosphor and commercially available phosphors exhibited good white-light emission under the excitation of an ultraviolet chip. The BaMoO 4 :0.08Eu 3+ red phosphors that rapidly synthesized under the microwave field are expected to be used in w-LED devices.

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G-Quartet Oligonucleotides

Cited by 125 publications

References 44 publications

Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Materials Science and Nanotechnology of Nucleic Acids

Rapid synthesis of BaMoO₄:Eu³⁺ red phosphors using microwave irradiation

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G-Quartet Oligonucleotides

Cited by 125 publications

References 44 publications

Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

Materials Science and Nanotechnology of Nucleic Acids

Rapid synthesis of BaMoO4:Eu3+ red phosphors using microwave irradiation

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Product

Resources

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Rapid synthesis of BaMoO₄:Eu³⁺ red phosphors using microwave irradiation