G-quadruplex structures at the promoter of HOXC10 regulate its expression

Zhang, Xiao; Zhao, Bo; Yan, Ting; Hao, Aixin; Gao, Yang; Li, Dangdang; Sui, Guangchao

doi:10.1016/j.bbagrm.2018.09.004

Cited by 16 publications

(8 citation statements)

References 45 publications

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“…Therefore, DDX3X might regulate Hox expression by maintaining transcript-associated rG4s. G4s also form within chromatin regulatory regions of DNA (dG4s) to control the transcription of Hox and other genes, and disruption of these structures has been implicated in cancer and neurodegeneration (Hansel-Hertsch et al, 2016;Lago et al, 2017;Zhang et al, 2018); therefore DDX3X might also regulate Hox-associated dG4s. Since Hox expression and brain development was largely unaffected in male Blbp-Cre +/-;Ddx3x Flx/Y mice, we propose that the paralog Ddx3y substitutes for Ddx3x during neurodevelopment, perhaps by substituting in rG4 and dG4s.…”

Section: Discussionmentioning

confidence: 99%

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

et al. 2020

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DDX3X is frequently mutated in the WNT and SHH subtypes of medulloblastomathe commonest malignant childhood brain tumor. But whether DDX3X functions as a medulloblastoma oncogene or tumor suppressor gene is not known. Here, we show that Ddx3x regulates hindbrain patterning and development by controlling Hox gene expression and cell stress signaling. In mice predisposed to Wnt or Shhmedulloblastoma, Ddx3x sensed oncogenic stress and suppressed tumor formation. WNT and SHHmedulloblastomas normally arise only in the lower and upper rhombic lips, respectively. Deletion of Ddx3x removed this lineage restriction, enabling both medulloblastoma subtypes to arise in either germinal zone.Thus, DDX3X is a medulloblastoma tumor suppressor that regulates hindbrain development and restricts the competence of cell lineages to form medulloblastoma subtypes.

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Section: Discussionmentioning

confidence: 99%

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

et al. 2020

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“…( 103 ) analyzed DNA sequences upstream of the HOXC10 transcription start site, verified the formation of G-quadruplex structures in the negative strand of the HOXC10 promoter and revealed that these structures could inhibit HOXC10 expression. These authors also confirmed that CHD7, a chromatin remodeling protein with DNA helicase activity, could associate with the HOXC10 promoter and likely unwind the G4 structures to enhance its gene expression ( 103 ). Conversely, Li et al.…”

Section: Hoxc10 Expression Regulationmentioning

confidence: 99%

Role of HOXC10 in Cancer

Fang

Wang

et al. 2021

Front. Oncol.

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The HOXC10 gene, a member of the HOX genes family, plays crucial roles in mammalian physiological processes, such as limb morphological development, limb regeneration, and lumbar motor neuron differentiation. HOXC10 is also associated with angiogenesis, fat metabolism, and sex regulation. Additional evidence suggests that HOXC10 dysregulation is closely associated with various tumors. HOXC10 is an important transcription factor that can activate several oncogenic pathways by regulating various target molecules such as ERK, AKT, p65, and epithelial mesenchymal transition-related genes. HOXC10 also induces drug resistance in cancers by promoting the DNA repair pathway. In this review, we summarize HOXC10 gene structure and expression as well as the role of HOXC10 in different human cancer processes. This review will provide insight into the status of HOXC10 research and help identify novel targets for cancer therapy.

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“…The G-rich sequences in this region has well been studied and shown to form a parallel G-quadruplex [99]. In addition to the c-myc , there are many G-quadruplexes that have been proven to form in the promoter regions, such as proto-oncogenes VEGF [97,100], bcl-2 [95,101], c-kit [102], HIF-1 [103], RET [104], and PDGF-A [105]; DNA repair gene RAD17 [106]; the human platelet-derived growth factor receptor beta PDGFR-β [96,107]; the homeobox gene HOXC10 [108]; the androgen receptor gene AR [109,110]; or human myosin gene ( MYH7 ) [111]. The formation of G-quadruplexes in these promoter regions hinders the interactions between DNA and its transcription factors, which in turn regulate the transcription.…”

Section: G-quadruplexesmentioning

confidence: 99%

Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

et al. 2019

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G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized.

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G-quadruplex structures at the promoter of HOXC10 regulate its expression

Cited by 16 publications

References 45 publications

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

Role of HOXC10 in Cancer

Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

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