G-Protein β
            <sub>3</sub>
            Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension

Poch, Esteban; González, Diego López; Gómez-Angelats, Elisenda; Enjuto, Montserrat; Jc, Paré; Rivera, Francisca; Sierra, Alejandro de la

doi:10.1161/01.hyp.35.1.214

Cited by 70 publications

(52 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, the relation was apparent in both parents and offspring analysed separately. This observation, in agreement with most of the studies evaluating the influence of the GNB3 on parameters of left ventricular function and structure, 8,10,11 has provided evidence for early onset and stability of this association over generations. Ageing is associated with alterations in functions of cardiac and vascular G-protein receptors with a potential to impair intracellular signalling and the ultimate cardiovascular phenotype.…”

supporting

confidence: 90%

mentioning

confidence: 99%

“…In addition, the early studies in Caucasian populations have demonstrated that a distribution of the C825T genotypes among subjects of European origin ensures appropriate epidemiological representation of each variant in population samples of different size. [6][7][8] In light of these findings, a selection of this candidate by Olszanecka et al 9 in their study on genetic determinants of cardiovascular phenotypes is fully justified. They examined associations of the C825T polymorphism with blood pressures as well as indicators of left ventricular structure and function in two generations of Caucasian families.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

et al. 2003

View full text Add to dashboard Cite

The last 4 years were the era of genomewide scans in cardiovascular genetics. Since 1999, after publication of the first comprehensive genome linkage analysis of systolic blood pressure in humans, 1 more than 20 genomewide searches for hypertension genes have been reported. The number of detected cardiovascular quantitative trait loci (QTLs) has increased rapidly, forming a new dense QTL-map within the human genome. At present, a QTL for blood pressure or hypertension exists almost on every human chromosome. However, most of the detected QTLs do not overlap, even within populations of the same ethnic origin. Much remains to be done in further dissection of these regions in order to identify new, consistent positional genetic candidates of human hypertension. The use of such identified positional markers is needed in association studies following genomewide searches and remains a promising strategy in cardiovascular genetics. However, most of the genes tested currently for association with essential hypertension and related phenotypes are not identified based on their positional relation to a detected QTL but on their pathophysiological potential to affect cardiovascular functions. Approximately 100 genes have been tested as candidates in association studies with cardiovascular traits including left ventricular hypertrophy (LVH) and essential hypertension.The expression of genes encoding components of the renin-angiotensin system is upregulated in vascular and cardiac hypertrophy and remodelling.The ability of angiotensin-converting enzyme (ACE) inhibitors to induce the regression of hypertensive LVH and prevent ventricular remodelling after myocardial infarction provides a clinical correlate to these observations. Thus, insertion/deletion (I/D) polymorphism of the ACE gene has been tested as a potential risk factor of hypertensive LVH in numerous studies, and the proportion of negative and positive results appears to be roughly equal. 2 Studies on association between hypertensive LVH and polymorphisms within the genes encoding angiotensinogen and angiotensin II receptors have also provided conflicting results. 2 Single nucleotide polymorphisms (SNPs) within genes encoding G-protein subunits belong to the most promising candidates in investigations on genetic determinants of LVH and essential hypertension, since the most important receptors in cardiovascular system have been linked to these intracellular signal messengers. 3 A SNP in exon 10 (C825T) of the G-protein b3 subunit gene is associated with alternative splicing. 4 The splice variant (Gb3s) occurring with T allele has been shown to enhance intracellular signal transmission with a potential to affect vascular reactivity, and cell growth. 5 These functional consequences of C825T polymorphism demonstrated at a molecular level as well as ubiquitous expression of this gene in cardiovascular system make the GNB3 an optimal target in pursuit of genes for human hypertension and its cardiac complications. In addition, the early studies in Caucasian populations ha...

show abstract

supporting

confidence: 90%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

et al. 2003

View full text Add to dashboard Cite

show abstract

“…25 Two other reports involving hypertensive patients with and without left ventricular hypertrophy demonstrated a positive association between left ventricular mass and the 825T allele. 26,27 In contrast, a large population-based study did not reveal any association between cardiac structure and GNB3 T allele. 28 Association never proves causation.…”

Section: Discussionmentioning

confidence: 69%

Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein β3-subunit polymorphism C825T in White Europeans

et al. 2003

View full text Add to dashboard Cite

The 825T allele of the G-protein b 3 -subunit is associated with increased intracellular signalling. Its association with hypertension is inconsistent. We, therefore, studied the C825T polymorphism in relation to ambulatory blood pressure as well as left ventricular structure and function in two European populations. We genotyped 248 parents and 318 offspring, enrolled in the European Project on Genes in Hypertension in Cracow, Poland (n ¼ 286) and in Novosibirsk, Russian Federation (n ¼ 280). The 24-h ambulatory blood pressure was recorded using oscillometric SpaceLabs 90207 monitors. Within each centre, a single observer performed two-dimensionally guided M-mode echocardiography and Doppler sonography to measure left ventricular structure (American Society of Echocardiography conventions) and diastolic function: early (E) and late (A) peak diastolic inflow velocities. We used analysis of covariance and generalized estimating equations to allow for covariables and nonindependence among related subjects. Genotype frequencies were similar (P ¼ 0.25) in Cracow and Novosibirsk and amounted to 44.7% for CC, 47.2% for CT, and 8.1% for TT. Among parents (mean age: 51.3 years)Fbut not among offspring (mean age 25.1 years)F24-h, daytime and night time systolic blood pressures were 5-6 mmHg higher in TT homozygotes than in C allele carriers. In TT homozygous parents (À8.2 cm/sec, P ¼ 0.004) as well as in TT homozygous offspring (À7.5 cm/sec, P ¼ 0.02), the E-wave was significantly reduced, which in offspring also resulted in a lower E/A ratio (-0.25, P ¼ 0.002). Neither in parents nor in offspring, left ventricular mass index was associated with the C825T polymorphism. In conclusion, in TT homozygotes of both generations, early left ventricular relaxation was reduced. In TT homozygous parents, the latter observation might be because of the higher systolic pressure associated with the TT genotype.

show abstract

“…In the samples from Israeli subjects, genotyping of the GNB3 C825T polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism [13] . In the samples from Spanish subjects, genotyping was performed using a newly-developed low-density DNA microarray based on allele-specifi c probes [6] .…”

Section: Genotypingmentioning

confidence: 99%

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

et al. 2010

View full text Add to dashboard Cite

G-Protein β ₃ Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension

Cited by 70 publications

References 36 publications

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein β3-subunit polymorphism C825T in White Europeans

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

Contact Info

Product

Resources

About

G-Protein β 3 Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension

Cited by 70 publications

References 36 publications

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

Cardiovascular diseases and G-protein β3 subunit gene (GNB3) in the era of genomewide scans

Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein β3-subunit polymorphism C825T in White Europeans

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

Contact Info

Product

Resources

About

G-Protein β ₃ Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension