“…Group III fungal G␣-proteins play crucial roles in growth and development, including sporulation When ligands interact with their seven cognate transmembrane receptors, the GDP bound to the ␣-subunit and germination, and pathogenesis in diverse fungi (Liu and Dean 1997;Kays et al 2000;Liebmann et al is replaced with GTP, resulting in dissociation of the ␣GTP-subunit from the ␥-complex. The ␣-subunit with 2003; Zuber et al 2003). The cAMP/PKA system is also involved downstream of group III G␣-protein signaling GTP bound and the free ␥-complex may interact with many types of downstream effectors such as enzymes in some processes such as cell proliferation, development, stress response, mating, and virulence (Kü bler (adenylate cyclases, phosphodiesterases, phospholipases, etc.)…”