G-CSF treatment after myocardial infarction: Impact on bone marrow—derived vs cardiac progenitor cells

Brunner, Stefan; Hüber, Bruno; Fischer, R; Groebner, Michael; Hacker, Marcus; Dávid, Róbert; Zaruba, Marc-Michael; Vallaster, Marcus; Rischpler, Christoph; Wilke, Andrea; Gerbitz, Armin; Franz, Wolfgang-Michael

doi:10.1016/j.exphem.2008.01.011

Cited by 45 publications

(30 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Several reports suggest that acute cardiac injury involves the activation and recruitment of both resident cardiac progenitor cells and noncardiac progenitor cells from BM that home in to the site of injury. [13][14][15][16][17][18] In the absence of administration of external growth factors or progenitor cell therapies, the endogenous regenerative process is insufficient in a significant plurality, as evidenced by the occurrence of post-MI heart in ≈30% of patients. 19 Moreover, experimental studies have suggested the release of stem and progenitor cells into the circulation from BM niche, which could play an important role in the turnover of vascular endothelium and myocardial repair response after MI.…”

mentioning

confidence: 99%

Exosomes and Cardiac Repair After Myocardial Infarction

Sahoo¹,

Losordo

2014

Circulation Research

440

343

View full text Add to dashboard Cite

mentioning

confidence: 99%

Exosomes and Cardiac Repair After Myocardial Infarction

Sahoo¹,

Losordo

2014

Circulation Research

440

343

View full text Add to dashboard Cite

“…The effect of irradiation separates from marrow engraftment cannot be ruled out in these studies, but appears unlikely. Similarly, work by Zhao et al [20], as well as studies of the effects of marrow cells infusions on ischemic myocardium in both animals and patients, has also shown functional effects which did not seem to be explained by marrow cells converting to differentiated organ-specifi c cells [23,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Marrow Cell Infusion Attenuates Vascular Remodeling in a Murine Model of Monocrotaline-Induced Pulmonary Hypertension

Aliotta

Keaney

Warburton

et al. 2009

Stem Cells and Development

View full text Add to dashboard Cite

There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hypertension (PH). C57BL/6 mice were injected with MCT or saline weekly for 4 weeks. Cohorts were then infused with saline vehicle (vehicle) or WBM from C57BL/-Tg(UBC-GFP)30Scha/J mice, with or without previous TBI (WBM or WBM/ TBI). Four weeks later, right ventricular peak pressures (RVPP), right ventricular free wall-to-body weight ratios (RV/BW), and pulmonary vessel wall thickness-to-blood vessel diameter ratios (PVWT/D) were determined. WBM infusion and WBM following TBI induced increases in RVPP and RV/BW in saline-treated mice, while only TBI-exposed mice showed additional increases in PVWT/D. MCT increased RVPP, RV/BW, and PVWT/D in mice given vehicle or WBM alone, but not in mice given WBM/TBI. RVPP and RV/BW were not signifi cantly lower in MCT mice given WBM/TBI than in MCT mice treated with vehicle, but MCT-treated mice given WBM or TBI/ WBM had signifi cantly lower PVWT/D compared to MCT-treated mice given saline vehicle. No donor WBMderived pulmonary vascular cells were detected, suggesting that the observed effects of WBM infusion may be due to paracrine effects separate from cell conversions. The observation of PH after marrow infusion suggests an additional mechanism for lung toxicity seen in marrow transplantation. In conclusion, WBM alone appears to increase RVPP and RV/BW in normal mice but the combination of WBM and TBI attenuates MCT-induced PH.

show abstract

“…Stem cell factor and granulocyte-colony stimulating factor (G-CSF) facilitate homing of BM cells to the infarct zone [100]. G-CSF also causes increased and better migration of resident cardiac stem cells [166]. Whereas Yoon et al [167] showed the influence of vascular growth factor on increased angiogenesis and homing of endothelial progenitor cells from BM, Ryzhov et al [168] demonstrated that adenosine causes increased adhesion of endothelial progenitor cells to the vascular wall.…”

Section: Homingmentioning

confidence: 99%

Stem cells as therapy for cardiac disease — a review

Jezierska-Woźniak

Mystkowska²,

Tutas³

et al. 2011

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Acute myocardial infarction (AMI) is one of the most significant causes of morbidity and mortality worldwide. Stem cells represent an enormous chance to rebuild damaged heart tissue. Correct definition of the cardiac progenitors is necessary to understand heart development, and would pave the way for the use of cardiac progenitors in the treatment of heart disease. Identifying, purifying and differentiating native cardiac progenitor cells are indispensable if we are to overcome congenital and adult cardiac diseases. To understand their functions, physiology and action, cells are tested in animal models, and then in clinical trials. But because clinical trials yield variable results, questions about proper cardiac stem cells remain unanswered. Transplanted stem cells release soluble factors, acting in a paracrine fashion, which contributes to cardiac regeneration. Cytokines and growth factors have cytoprotective and neovascularizing functions, and may activate resident cardiac stem cells. Understanding all these mechanisms is crucial to overcoming heart diseases. (Folia Histochemica et

show abstract

G-CSF treatment after myocardial infarction: Impact on bone marrow—derived vs cardiac progenitor cells

Cited by 45 publications

References 23 publications

Exosomes and Cardiac Repair After Myocardial Infarction

Exosomes and Cardiac Repair After Myocardial Infarction

Marrow Cell Infusion Attenuates Vascular Remodeling in a Murine Model of Monocrotaline-Induced Pulmonary Hypertension

Stem cells as therapy for cardiac disease — a review

Contact Info

Product

Resources

About

G-CSF treatment after myocardial infarction: Impact on bone marrow—derived vs cardiac progenitor cells

Cited by 45 publications

References 23 publications

Exosomes and Cardiac Repair After Myocardial Infarction

Exosomes and Cardiac Repair After Myocardial Infarction

Marrow Cell Infusion Attenuates Vascular Remodeling in a Murine Model of Monocrotaline-Induced Pulmonary Hypertension

Stem cells as therapy for cardiac disease &#8212; a review

Contact Info

Product

Resources

About

Stem cells as therapy for cardiac disease — a review