G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

Luyckx, Ariane; Schouppe, Elio; Rutgeerts, Omer; Lenaerts, Caroline; Fevery, Sabine; Devos, Timothy; Dierickx, Daan; Waer, Mark; Ginderachter, Jo A. Van; Billiau, An

doi:10.1016/j.clim.2012.01.011

Cited by 85 publications

(89 citation statements)

References 12 publications

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“…High expression of M-CSF messenger RNA (mRNA) in mice correlates with expansion of MDSCs (Irvine et al 2006), and high levels of GM-CSF are associated with immune suppression and the increased generation of MDSCs (Dranoff et al 1993;Serafini et al 2004). In human donors, G-CSF administration to mobilise stem cells is accompanied by expansion of g-MDSCs (Luycx et al 2012). In addition, a broad range of cytokines and chemokines including transforming growth factor-β (TGF-β), IL-1β, IL-6, IL-10, IL-12, IL-13, CCchemokine ligand 2 (CCL-2), CXC-chemokine ligand 5 (CXCL-5) and CXC-chemokine ligand 12 (CXCL-12) have been shown to affect MDSC expansion and recruitment (reviewed in Ugel et al (2009)).…”

Section: Regulation Of Mdsc Expansionmentioning

confidence: 99%

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Bueno

Sant’Anna

Lord

2014

AGE

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Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naïve, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNFα and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction.

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Section: Regulation Of Mdsc Expansionmentioning

confidence: 99%

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Bueno

Sant’Anna

Lord

2014

AGE

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“…generally agreed that murine MDSCs are identified as CD11b + Gr-1 + cells, and various studies have attempted to investigate human MDSCs with various combinations of lineage markers [32][33][34][35][36], until a definitive marker is found, the phenotypic definition of MDSCs will remain ambiguous.…”

Section: Depletion Of Cd14 + Cells Restores T-cell Proliferation and mentioning

confidence: 99%

Myeloid Derived Suppressor Cells and Their Role in Diseases

Kong¹,

Fuchsberger

Xiang

et al. 2013

CMC

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Abstract:Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitors that can play a major role in tumour development and chronic inflammation. The importance of the suppressive function of MDSCs was first suggested by studies involving cancer patients and cancer-bearing mice. In addition, recent studies have demonstrated that MDSCs can also be involved in many other pathological conditions. MDSCs have unique ways of abrogating an immune response in addition to those utilised by other immune-suppressive cell types, for example via the induction of arginase-1 and consequent upregulation in reactive oxygen species (ROS) production. Due to their heterogeneity, they further can express a variety of lineage markers, which overlap with other myeloid cell types such as Gr1, CD11b, MHCII lo , Ly6C and Ly6G, making it difficult to identify them by surface phenotype alone. The disparity between mouse and human MDSCs further complicates the identification of these elusive cell populations. In this review, we will summarise the recent updates on the methods for eliciting and studying different MDSC subsets, including newly proposed surface phenotypes, as well as insights into how their function is being characterised in both mice and humans. In addition, exciting new discoveries suggesting their involvement across a number of different pathological settings, such as sepsis, autoimmunity and Leishmaniasis, will be discussed.

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“…It was revealed that tumor-induced granulocyte colony-stimulating factor (G-CSF) is one of those factors (Waight et al 2011;Abrams and Waight 2012;Luyckx et al 2012;Kawano et al 2015). Our recent study also showed that the serum G-CSF level is associated with the inhibition of expansion and differentiation of G-MDSCs in tumor-bearing adiponectin knockout mice (Han et al 2013).…”

Section: The Subsets Of Mdscsmentioning

confidence: 90%

Phenotypic and functional dissection of myeloid-derived suppressor cells

Han

Yang

2016

Appl Biol Chem

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Myeloid-derived suppressor cells (MDSCs) are originated and differentiated population from common hematopoietic progenitor cells. Generally, in the late stage of inflammation, MDSCs differentiation and expansion are promoted to suppress the over-activated immune system so that the immune system can maintain the homeostasis. Recently, it has been revealed that MDSCs accumulate in cancer patients and tumor-bearing experimental animals, and these tumor-derived MDSCs suppress anti-tumor immunity by secreting immunosuppressive cytokines including reactive oxygen species and inducible nitric oxide synthase. This fact prompts scientists to shed light on MDSCs as significant targets for anti-cancer immunotherapy. However, due to morphological, phenotypic, and functional heterogeneities of MDSCs, it is not easy to develop therapeutic strategies targeting MDSCs. In this review, we will summarize recent progress on defined subsets of MDSCs and their strategies to suppress T cellmediated anti-tumor immunity.

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G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

Cited by 85 publications

References 12 publications

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Myeloid Derived Suppressor Cells and Their Role in Diseases

Phenotypic and functional dissection of myeloid-derived suppressor cells

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