G-CSF Production by Undifferentiated Pleomorphic Sarcoma with Leukemoid Reaction Occurred in the Lower Leg

Hayashida, Kenta; Kawabata, Yusuke; Kato, Ikuo; Suzuki, Michiaki; Takeyama, Masanobu; Inaba, Yutaka

doi:10.2106/jbjs.cc.19.00624

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Undifferentiated sarcoma does not have the disorderly, fine branching lace-like structure of EOS [ 12 ]. Clinically, undifferentiated/unclassified sarcoma and EOS are common in adult limbs, which are prone to cystic degeneration and bleeding, but undifferentiated/unclassified sarcomas have more fibrous components or fibrous septa, a low signal on T2WI, and progressive or continuous enhancement in parenchyma [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma

Wang,

Zhang,

Lin

et al. 2024

BMC Cancer

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Objective The aim of this study was to investigate the clinical, imaging and pathological features of extraskeletal osteosarcoma (EOS) and to improve the understanding of this disease and other similar lesions. Methods The data for 11 patients with pathologically confirmed extraosseous osteosarcoma, including tumour site and size and imaging and clinical manifestations, were analysed retrospectively. Results Six patients were male (60%), and 5 were female (40%); patient age ranged from 23 to 76 years (average age 47.1 years). Among the 11 patients, 7 had clear calcifications or ossification with different morphologies, and 2 patients showed a massive mature bone tumour. MRI showed a mixed-signal mass with slightly longer T1 and T2 signals in the tumour parenchyma. Enhanced CT and MRI scans showed enhancement in the parenchyma. Ten patients had different degrees of necrosis and cystic degeneration in the mass, 2 of whom were complicated with haemorrhage, and MRI showed “fluid‒fluid level” signs. Of the 11 patients, five patients survived after surgery, and no obvious recurrence or metastasis was found on imaging examination. One patient died of lung metastasis after surgery, and 2 patients with open biopsy died of disease progression. One patient died of respiratory failure 2 months after operation. 2 patients had positive surgical margins, and 1 had lung metastasis 6 months after operation and died 19 months after operation. Another patient had recurrence 2 months after surgery. Conclusion The diagnosis of EOS requires a combination of clinical, imaging and histological examinations. Cystic degeneration and necrosis; mineralization is common, especially thick and lumpy mineralization. Extended resection is still the first choice for localized lesions. For patients with positive surgical margins or metastases, adjuvant chemoradiotherapy is needed.

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Section: Discussionmentioning

confidence: 99%

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma

Wang,

Zhang,

Lin

et al. 2024

BMC Cancer

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“…Our case manifests as a soft tissue mass of the lower limb with intense FDG uptake on PET/CT mimicking malignancy. When soft tissue masses of the lower limbs are encountered, lymphoma, 5 epithelioid hemangioendothelioma, 6 alveolar soft part sarcoma, 7 undifferentiated pleomorphic sarcoma, 8 IgG4-related disease, 9 metastasis, 10,11 intramuscular myxoma, 12 and malignant peripheral nerve sheath tumor 13 should be considered in the differential diagnosis. Except for myxoma (mild FDG uptake), these lesions could have intense FDG uptake.…”

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confidence: 99%

Angiofibroma of Soft Tissue on MRI and FDG PET/CT Image

Liu

Wang

et al. 2022

Clin Nucl Med

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Angiofibroma of soft tissue is a rare benign mesenchymal neoplasm. We reported a case of angiofibroma of soft tissue in a 61-year-old woman. MRI examination indicated a soft tissue mass in the right lower thigh, which showed isosignal intensity on T1-weighted imaging and heterogeneous high signal intensity on T2-weighted imaging. This lesion had intense tracer uptake, with an SUV max of 7.24 on FDG PET/CT. Our case revealed that when soft tissue masses with intense FDG uptake on PET/ CT are encountered, angiofibroma of soft tissue should be considered in the differential diagnosis.

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Inflammatory Undifferentiated Pleomorphic Sarcoma Mimicking Bacteremia in an Elderly Patient: A Case Report

et al. 2021

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Undifferentiated pleomorphic sarcoma (UPS) is major type of soft tissue sarcomas. UPS presenting with inflammation is rare, and its pathophysiology remains unclear. Herein, we report a rare case of UPS with prolonged fever. A 91-year-old female complaining of high fever was referred to our hospital because of a high C-reactive protein (CRP) level of 12.51 mg/dL. She had been experiencing intermittent fevers for approximately 10 years. The fever of unknown origin worsened with time and went into remission with repeated antimicrobial therapy. She also had a mass on her central lower back over the sacral region for 6 years, which showed a gradual increase in size. The blood tests showed that the leukocyte count and neutrophils were 6.51 × 103 µ/L and 70.3%, respectively. She had a 10 × 10 cm mass on her buttock that showed 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) accumulation on FDG-positron emission tomography-computed tomography examination (standardized uptake value-max value: 5.4). A blood culture examination was performed to rule out bacteremia, however, no bacteria were identified. We then performed a needle biopsy and confirmed the diagnosis of UPS; subsequently, the patient underwent a wide-margin resection. A few days after the surgery, her CRP, leukocyte, and neutrophil levels decreased to 0.305 mg/dL, 2.83 × 103/uL, and 50.1%, respectively. This case demonstrated that UPS with inflammation should be treated surgically as soon as possible after ruling out other sources of infection to achieve a favorable prognosis.

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G-CSF Production by Undifferentiated Pleomorphic Sarcoma with Leukemoid Reaction Occurred in the Lower Leg

Cited by 3 publications

References 13 publications

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma

Angiofibroma of Soft Tissue on MRI and FDG PET/CT Image

Inflammatory Undifferentiated Pleomorphic Sarcoma Mimicking Bacteremia in an Elderly Patient: A Case Report

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