G-CSF-producing esophageal cancer with induction of intense bone marrow FDG uptake

Oshikiri, Taro; Yasuda, Takashi; Ohyama, Masato; Hasegawa, Hiroshi; Ohara, Tadayuki; Sendo, Hiroyoshi; Sugimoto, Takemi; Fujino, Yasuhiro; Tominaga, Masahiro; Takahashi, Yuichi

doi:10.1007/s10388-014-0421-0

Cited by 5 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, clinically, positive immunostaining is not a definitive finding for the diagnosis of G-CSF-producing tumors (11). It has been suggested that the rapid secretion of G-CSF without intracellular retention is the reason why such tumors may exhibit negative staining with an anti-G-CSF monoclonal antibody (12).…”

Section: Discussionmentioning

confidence: 99%

“…In a PubMed search, 14 case reports (13-26) and 6 cited publications (11,(27)(28)(29)(30)(31) regarding G-CSF-producing upper gastrointestinal tract cancers, including esophageal cancer (12 cases), EGJ cancer (1 case), and gastric cancer (7 cases), were retrieved from the English-language literature. Demographic and clinical characteristics for all of the described cases of such cancers, including the present case, are summarized in Table I.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

View full text Add to dashboard Cite

Abstract. The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion. Therefore, this tumor was clinically diagnosed as a G-CSF-producing liver metastasis from EGJ cancer, although immunohistochemical staining for G-CSF was negative. A right pulmonary nodule detected simultaneously with the hepatic mass was resected four months following the hepatectomy and was diagnosed as a pulmonary metastasis. The patient's leukocyte count was normal at the time of her initial surgery for EGJ cancer, and her clinical course varied for different metastatic sites. The liver metastasis was accompanied by progressive leukocytosis and elevated serum G-CSF and demonstrated rapid tumor growth during a six-month period, whereas the non-G-CSF-producing pulmonary metastasis grew slowly during the same period. In addition 21 reported cases of G-CSF-producing upper gastrointestinal tract cancer were reviewed to elucidate the clinicopathological features of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…study, a combination of chemotherapy and radiation therapy was employed, and the choroidal mass decreased without major adverse events. Previous reports showed that radical tumor resection induced a rapid decrease in both WBC count and serum G-CSF levels [17,18]. In this study, chemoradiation therapy was performed instead of radical tumor resection, which induced normalization of WBC count.…”

Section: Discussionmentioning

confidence: 81%

“…Previous reports showed that radical tumor resection induced a rapid decrease in both WBC count and serum G‐CSF levels . In this study, chemoradiation therapy was performed instead of radical tumor resection, which induced normalization of WBC count.…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Choroidal metastasis from granulocyte colony‐stimulating factor‐producing esophageal squamous cell carcinoma: a case report

Fukuda

Fujiwara

Mishima

et al. 2017

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Favorable response to pembrolizumab in granulocyte colony‐stimulating factor‐producing upper urinary tract urothelial carcinoma

et al. 2021

View full text Add to dashboard Cite

Introduction Granulocyte colony‐stimulating factor‐producing upper urinary tract urothelial carcinoma is rare, with a poor prognosis. Advanced urothelial carcinoma is currently treated with immune checkpoint inhibitors, whose efficacy for granulocyte colony‐stimulating factor‐producing upper urinary tract urothelial carcinoma remains unclear. Case presentation A 66‐year‐old male diagnosed with clinical stage T3N1M0 urothelial carcinoma of the right ureter with giant hydronephrosis underwent right radical nephroureterectomy. Local recurrence, leukocytosis, and elevated serum granulocyte colony‐stimulating factor levels were observed approximately 3 months after surgery. Chemotherapy was started but failed to control the disease. Therefore, pembrolizumab was chosen as the second‐line treatment. After this treatment, the blood leukocyte count rapidly normalized, and a clinically favorable response was achieved. There was no recurrence 10 months after the beginning of pembrolizumab treatment, which is still ongoing. Conclusion Pembrolizumab may be a treatment option for advanced granulocyte colony‐stimulating factor‐producing upper urinary tract urothelial carcinoma.

show abstract

G-CSF-producing esophageal cancer with induction of intense bone marrow FDG uptake

Cited by 5 publications

References 18 publications

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Choroidal metastasis from granulocyte colony‐stimulating factor‐producing esophageal squamous cell carcinoma: a case report

Favorable response to pembrolizumab in granulocyte colony‐stimulating factor‐producing upper urinary tract urothelial carcinoma

Contact Info

Product

Resources

About