G-CSF inhibits LFA-1-mediated CD4+ T cell functions by inhibiting Lck and ZAP-70

Zhao, Shasha; Gu, Zhenyang; Wang, Li; Guan, Li; Wang, Feiyan; Yang, Nan; Luo, Lan; Gao, Zhe; Song, Yingwei; Wang, Lili; Liu, Dai‐Hong; Gao, Chen

doi:10.18632/oncotarget.18194

Cited by 2 publications

(1 citation statement)

References 58 publications

(70 reference statements)

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“…PI3Kδ also facilitates T cell activation by increasing LFA-1/ICAM-1 interaction ( 35 ). And G-CSF inhibits LFA-1/ICAM-1-mediated CD4 + T cells inflammatory cytokines secretion by down-regulating Lck and ZAP-70 ( 36 ). CD8 + T cell has intracellular LFA-1 storage, which can be transported to cell surface after antigenic stimulation and is an important mechanism for LFA-1 to regulate T cell differentiation ( 37 ).…”

Section: Lfa-1 and Icam-1mentioning

confidence: 99%

Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application

Yang

Miao²,

Yu³

et al. 2023

Front. Oncol.

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Advanced non-small cell lung cancer (NSCLC) is a severe disease and still has high mortality rate after conventional treatment (e.g., surgical resection, chemotherapy, radiotherapy and targeted therapy). In NSCLC patients, cancer cells can induce immunosuppression, growth and metastasis by modulating cell adhesion molecules of both cancer cells and immune cells. Therefore, immunotherapy is increasingly concerned due to its promising anti-tumor effect and broader indication, which targets cell adhesion molecules to reverse the process. Among these therapies, immune checkpoint inhibitors (mainly anti-PD-(L)1 and anti-CTLA-4) are most successful and have been adapted as first or second line therapy in advanced NSCLC. However, drug resistance and immune-related adverse reactions restrict its further application. Further understanding of mechanism, adequate biomarkers and novel therapies are necessary to improve therapeutic effect and alleviate adverse effect.

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Section: Lfa-1 and Icam-1mentioning

confidence: 99%

Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application

Yang

Miao²,

Yu³

et al. 2023

Front. Oncol.

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Evaluation of granulocyte colony-stimulating factor effect on the expression of inhibitory receptors by T cells in multiple myeloma

Batorov,

Aristova,

Denisova

et al. 2024

Med. immunol.

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All types of immune cells are involved in the pathogenesis of multiple myeloma (MM). Granulocytic (G-MDSCs) and monocytic myeloid-derived suppressor cells (M-MDSCs) have significant protumor effects. The T cell immune response may be reduced due to the development of T cell exhaustion, characterized by the expression of inhibitory receptors PD-1, TIM-3, etc. Granulocyte colony-stimulating factor (G-CSF) supports the generation and expansion of MDSCs and can influence the functional properties of T cells. The purpose of our work was to investigate the possible effect of stimulation with G-CSF drugs on the induction of PD-1 and TIM-3 expression by T cells in patients with MM. The study included 40 patients with MM who underwent mobilization of hematopoietic progenitor cells with G-CSF drugs (5 mcg/kg/day) for 4-5 days. Content of CD4+PD-1+, CD4+TIM-3+, CD8+PD-1+, CD8+TIM-3+T cells, Lin-HLA-DR-CD33+CD66b+G-MDSCs, and CD14+HLA-DR-M-MDSCs was assessed before the start of a course of G-CSF injections (n = 33), after a course of G-CSF on the first day of separation of hematopoietic progenitor cells (n = 28) and after 3-6 months (n = 40) by flow cytometry. The relative content of G-MDSCs and M-MDSCs was significantly higher in patients with MM after a course of G-CSF. After 3-6 months, the content of G-MDSCs and M-MDSCs decreased to the initial values. After the course of G-CSF, an increase in the content of CD4+PD-1+T cells was noted compared to the values before the study. After 3-6 months, the content of this population did not differ from the initial values. The relative numbers of CD4+TIM-3+, CD8+PD-1+, and CD8+TIM-3+T cells did not change after a course of G-CSF. There were no significant correlations between the content of the populations of MDSCs and T cells expressing PD-1 and TIM-3 after a course of G-CSF.Mobilization of hematopoietic stem cells by G-CSF in patients with MM is accompanied by a transient increase in MM populations and an isolated increase in CD4+PD-1+T cells.

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G-CSF inhibits LFA-1-mediated CD4+ T cell functions by inhibiting Lck and ZAP-70

Cited by 2 publications

References 58 publications

Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application

Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application

Evaluation of granulocyte colony-stimulating factor effect on the expression of inhibitory receptors by T cells in multiple myeloma

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