G cells and gastrin in chronic alcohol-treated rats

Todorovic, Vesna; Koko, Vesna; Budeč, Mirela; Mićić, Mileva; Micev, Marjan; Pavlović, Mirjana; Vignjević, Sanja; Drndarević, Neda; Mitrović, Olivera

doi:10.1016/j.alcohol.2007.10.004

Cited by 5 publications

(2 citation statements)

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“…A variety of agents can induce gastric mucosal injury if they overwhelm gastric defenses. Among them, alcohol is a well‐recognized causative agent for gastric mucosal damage [22]. Chronic alcohol consumption usually causes the shrinkage of gastric mucosa and decreases the gastric secretory capacity [4,5].…”

Section: Discussionmentioning

confidence: 99%

Phloroglucinol protects gastric mucosa against ethanol-induced injury through regulating myeloperoxidase and catalase activities

Luo

Zhang

et al. 2010

Fundamental &Amp; Clinical Pharmacology

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It has been shown that oxidative stress plays an important role in the pathogenesis of ethanol-induced acute gastric mucosal injury, and phloroglucinol, a smooth muscle relaxant, has been reported to possess anti-oxidative properties. In this study, we explored the effect of phloroglucinol on ethanol-induced gastric mucosal injury and the possible underlying mechanisms. The rat model of gastric mucosal injury was induced by oral administration of acidified ethanol, and the gastric tissues were collected for analysis of gastric ulcer index (UI), cellular apoptosis, anti-O(2) ˙ or OH˙ formation activity, malondialdehyde (MDA) content, and the activities of myeloperoxidase (MPO), catalase and glutathione peroxidase. The results showed that acute administration of ethanol significantly increased gastric UI concomitantly with the increased cellular apoptosis, MDA contents, MPO activity as well as the decreased activities of catalase and anti-O(2) ˙ or OH˙ formation, which was reversed by pretreatment with phloroglucinol. Although ethanol treatment significantly decreased the activity of glutathione peroxidase, pretreatment with phloroglucinol did not significantly affect the activity of the same. The results suggest that phloroglucinol could protect the gastric mucosa against ethanol-induced injury, which is related to inhibiting the MPO activity and increasing the catalase activity in the gastric tissues.

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Section: Discussionmentioning

confidence: 99%

Phloroglucinol protects gastric mucosa against ethanol-induced injury through regulating myeloperoxidase and catalase activities

Luo

Zhang

et al. 2010

Fundamental &Amp; Clinical Pharmacology

View full text Add to dashboard Cite

show abstract

“…The details are presented in table 1. Also the changes in the number of D and G cells in atrophic gastritis were observed and several studies presented the therapy promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism in rats (Zhu et al, 2008;Wang et al, 2009;Czaja et al, 2008;Todorovic et al, 2008). However, as it was reported (Czaja et al, 2008), changes of serum gastrin concentration in gastric antrum in children with chronic gastritis are not statistically significantly connected with D and G cell densities.…”

Section: Diagnostic Influence Of Neuroendocrine Cell Morphometrymentioning

confidence: 46%