G.ALPHA.13 Induces PreproET-1 Gene Expression via JNK.

Abstract

The endothelin B receptor (ETBR) has been shown to mediate autoinduction of endothelin-1 (ET-1). We previously reported that the ETBR interacts with G 13, a member of the heterotrimeric GTP-binding protein family.In the present study, we examined whether G 13 induces preproET-1 (ppET-1) gene transcription, which could result in ET-1 autoinduction in a renal epithelial cell line. We generated a reporter gene construct un-

Impaired angiotensin II–extracellular signal-regulated kinase signaling in failing human ventricular myocytes

“…In conclusion, these experiments confirm the redundant role of JNK in ET-1 release [32,33] that is conceivable with the effect of JNK downstream from ERK [34].…”

Thrombin-Induced Endothelin-1 Synthesis and Secretion in Retinal Pigment Epithelial Cells Is Rho Kinase Dependent

“…25,26 Activated Ga 13 induces ppET-1 transcription in c-jun N-terminal kinase-dependent manner. 46 Additionally, rho GTPases have been implicated in regulating ET-1 synthesis by increasing endothelin converting enzyme (ECE-1) mRNA. 47 Active Rho/ROCK have also been shown to initiate transcription by directly regulating the activity of AP-1 family of transcription factors.…”

Mechanisms of fibrinogen‐induced microvascular dysfunction during cardiovascular disease

“…Activation of ERK-1/2 is involved in Fg-induced regulated production of ET-1 (Sen et al 2009). A role of the JNKmediated pathway in production of prepro-ET-1 gene transcription has also been demonstrated (Yamakaw et al 2002). However, the role of these MAPKs in ET-1 production during hypertension is not established.…”

“…2009). A role of the JNK‐mediated pathway in production of prepro‐ET‐1 gene transcription has also been demonstrated (Yamakaw et al. 2002).…”