G 2 /M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph 3 PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

Abstract

for 1-3). Finally, the zebrafish tolerated doses of 1 and 2 up to 0.625 µM, and 3 was tolerated at even higher doses of up to 1.25 µM.

Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

“…Cancer cells generally carry extra copies of DNA as a consequence of abnormal DNA replication, which gives rise to the feasibility of targeting DNA by therapeutics [ 122 , 123 ]. The formation of DNA adducts alters DNA structure and subsequently, renders cancer cells incapable of proceeding to the different checkpoints of the cell cycle for replication, resulting in targeted cancer cell death [ 124 ]. Although cancer cell death can be achieved effectively, chemotherapy is often non-selective and targets the DNA of normal cells as well to causing undesirable side effects [ 125 , 126 ].…”

Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

“…Apoptosis assay can provide important information for the preliminary investigation of the mode of action [ 55 , 56 , 57 ]. To determine whether the death of MGC80-3 cells induced by complex 1 resulted from apoptosis or necrosis, common biochemical markers of apoptosis were monitored, including mitochondrial membrane depolarization, chromatin condensation, and phosphatidylserine exposure.…”

Crystal structure of chlorido-(O-methyl phenylcarbamothioamide-κS)-bis(triphenylphosphane-κP)silver(I), C44H39AgClNOP2S

“…The synthesis and characterisation of the title compound, (Ph 3 P) 2 Ag[S=C(OMe)N(H)Ph]Cl, (I), was motivated by the biological potential exhibited by their phosphanegold(I) thiolate counterparts of general formula R 3 PAu[SC(OR′)=NAr]. These have proven to be potent against bacteria, especially Grampositive bacteria [7] and against a number of cancer cell lines, inducing cell death via apoptotic pathways [8].…”