FYN: emerging biological roles and potential therapeutic targets in cancer

Peng, Sanfei; Fu, Yang

doi:10.1186/s12967-023-03930-0

Cited by 22 publications

(16 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fyn regulates multiple signals by phosphorylating signaling molecules and thus participates in physiological processes. [ 28 , 29 ] From the published papers, the effects of Fyn on kidney disease are consistent with our study. For example, activated Fyn augments oxidative stress, inflammation, endoplasmic reticulum stress, and autophagy dysfunction, resulting in the progression of acute kidney disease (AKI).…”

Section: Discussionsupporting

confidence: 91%

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Xie,

Yuan,

Cao

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Nuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD). However, the role of nuclear receptor coactivators that are powerful enhancers for the transcriptional activity of NRs in DKD remains unclear. In this study, a significant decrease in Nuclear Receptor Coactivator 3 (NCOA3) is observed in injured podocytes caused by high glucose treatment. Additionally, NCOA3 overexpression counteracts podocyte damage by improving autophagy. Further, Src family member, Fyn is identified to be the target of NCOA3 that mediates the podocyte autophagy process. Mechanistically, NCOA3 regulates the transcription of Fyn in a nuclear receptor, PPAR‐γ dependent way. Podocyte‐specific NCOA3 knockout aggravates albuminuria, glomerular sclerosis, podocyte injury, and autophagy in DKD mice. However, the Fyn inhibitor, AZD0530, rescues podocyte injury of NCOA3 knockout DKD mice. Renal NCOA3 overexpression with lentivirus can ameliorate podocyte damage and improve podocyte autophagy in DKD mice. Taken together, the findings highlight a novel target, NCOA3, that protects podocytes from high glucose injury by maintaining autophagy.

show abstract

Section: Discussionsupporting

confidence: 91%

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Xie,

Yuan,

Cao

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…FYN plays an essential role in diverse cellular processes 28,29 . In addition, previous studies showed that FYN served as a tumor accelerator in multiple cancers 17,30,31 . Moreover, Liu et al disclosed that FYN expression was elevated in EC tissue specimens, and FYN silence restrained cell growth and facilitated apoptosis in EC cells 19,20 .…”

Section: Discussionmentioning

confidence: 99%

“… 28 , 29 In addition, previous studies showed that FYN served as a tumor accelerator in multiple cancers. 17 , 30 , 31 Moreover, Liu et al disclosed that FYN expression was elevated in EC tissue specimens, and FYN silence restrained cell growth and facilitated apoptosis in EC cells. 19 , 20 Here, FYN was also observed to be overexpressed in EC tissue specimens and EC cell lines.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

Chu,

Sun,

Liu

et al. 2024

Thoracic Cancer

View full text Add to dashboard Cite

BackgroundCircular RNAs (circRNAs) play critical roles in the tumorigenesis and radiosensitivity of multiple cancers. Nevertheless, the biological functions of circRNA periostin (circ‐POSTN) in esophageal cancer (EC) progression and radiosensitivity have not been well elucidated.MethodsThe expression of circ‐POSTN, microRNA‐876‐5p (miR‐876‐5p), and proto‐oncogene tyrosine‐protein kinase (FYN) was analyzed by quantitative reverse transcription PCR (RT‐qPCR). Cell proliferation was assessed by MTT, colony formation, and 5‐ethynyl‐2′‐deoxyuridine (EDU) assays. All protein levels were detected by western blot assay. Cell apoptosis and invasion were assessed by flow cytometry analysis and transwell assay, respectively. Dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays were used to validate the interaction between miR‐876‐5p and circ‐POSTN or FYN. The role of circ‐POSTN in vivo was explored by establishing mice xenograft model.ResultsCirc‐POSTN was overexpressed in EC tissues and cells. Knockdown of circ‐POSTN inhibited cell proliferation and invasion and elevated apoptosis and radiosensitivity in EC cells. MiR‐876‐5p was a direct target of circ‐POSTN, and its knockdown reversed the role of sh‐circ‐POSTN in EC cells. FYN was a direct target of miR‐876‐5p, and FYN elevation weakened the effects of miR‐876‐5p overexpression on the progression and radiosensitivity of EC cells. Moreover, circ‐POSTN acted as a miR‐876‐5p sponge to regulate FYN expression. Circ‐POSTN interference also suppressed tumor growth and enhanced radiosensitivity in vivo.ConclusionCirc‐POSTN knockdown inhibited proliferation and invasion, but increased apoptosis and enhanced radiosensitivity in EC cells via modulating miR‐876‐5p/FYN axis, which might be a potential diagnostic and therapeutic target for EC.

show abstract

“…PTPs are known to be signaling molecules that regulate a variety of cellular processes [ 46 ]. FYN (FYN proto-oncogene, Src-family tyrosine kinase) is a member of the protein–tyrosine kinase oncogene family that plays roles in many biological processes, including regulating cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility and the immune response [ 47 ]. As well as the strong signals from the immune-system processes, some other interesting pathways were highlighted in the commercial birds.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression

Sadr

Nassiri

Ghaderi–Zefrehei

et al. 2023

Genes

View full text Add to dashboard Cite

The purpose of the current study was to examine transcriptomic-based profiling of differentially expressed innate immune genes between indigenous and commercial chickens. In order to compare the transcriptome profiles of the different chicken breeds, we extracted RNA from blood samples of the Isfahan indigenous chicken (as indigenous) and Ross broiler chicken (as commercial) breeds. RNA-Seq yielded totals of 36,763,939 and 31,545,002 reads for the indigenous and commercial breeds, respectively, with clean reads then aligned to the chicken reference genome (Galgal5). Overall, 1327 genes were significantly differentially expressed, of which 1013 genes were upregulated in the commercial versus the indigenous breed, while 314 were more highly expressed in the indigenous birds. Furthermore, our results demonstrated that the SPARC, ATP6V0D2, IL4I1, SMPDL3A, ADAM7, TMCC3, ULK2, MYO6, THG1L and IRG1 genes were the most significantly expressed genes in the commercial birds and the PAPPA, DUSP1, PSMD12, LHX8, IL8, TRPM2, GDAP1L1, FAM161A, ABCC2 and ASAH2 genes were the most significant in the indigenous chickens. Of notable finding in this study was that the high-level gene expressions of heat-shock proteins (HSPs) in the indigenous breeds could serve as a guideline for future genetic improvement. This study identified genes with breed-specific expression, and comparative transcriptome analysis helped understanding of the differences in underlying genetic mechanisms between commercial and local breeds. Therefore, the current results can be used to identify candidate genes for further breed improvement.

show abstract

FYN: emerging biological roles and potential therapeutic targets in cancer

Cited by 22 publications

References 185 publications

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression

Contact Info

Product

Resources

About