FV 8. The effect of repeated blocks of intermittant theta burst stimulation (iTBS) over the dorsolateral prefrontal cortex (dlPFC) on fronto-striatal connectivity. A 18F-DesmethoxyFallypride (DMFP) Positron Emission Tomography study (PET)

Shaikh, U.J.; Pellicano, Antonello; Schüppen, André; Heinzel, Alexander; Mottaghy, Felix; Binkofski, Ferdinand

doi:10.1016/j.clinph.2021.02.384

Cited by 2 publications

(2 citation statements)

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“…Indeed, this top-down regulation may specifically trigger striatal dopamine release. Recently, Shaikh et al (2024) demonstrated through PET that subthreshold iTBS over L-DLPFC induces striatal dopamine release (Shaikh, Pellicano et al 2024, Shaikh, Pellicano et al 2024). Striatal dopamine is critical for many vital processes, including motivation, motor learning, and reinforcement learning, striatal dopamine supports reward expectation and learning (Calabro, Montez et al 2023).…”

Section: Discussionmentioning

confidence: 99%

“…Iwabuchi et al (2017) reported that subthreshold iTBS over the L-DLPFC significantly dampened fronto-insular connectivity and reduced GABA/Glu and GABA/Glu had a significant mediating effect on iTBS-induced changes in DLPFC-to-right anterior insula connectivity (Iwabuchi, Raschke et al 2017). Recent studies have also shown that subthreshold iTBS over the L-DLPFC leads to DA release in the striatum using PET (Shaikh, Pellicano et al 2024, Shaikh, Pellicano et al 2024). In a clinical context, suprathreshold iTBS over L-DLPFC increased cortical GABA and Glu in treatment-resistant depression (Spurny-Dworak, Godbersen et al 2022).…”

Section: Discussionmentioning

confidence: 99%

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Intermittent theta burst stimulation (iTBS)-induced changes of resting-state brain entropy (BEN)

Liu,

Song,

Deng

et al. 2024

Preprint

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Intermittent theta burst stimulation (iTBS) is a novel protocol of repetitive transcranial magnetic stimulation (rTMS). While iTBS has shown better therapeutic effects for depression than conventional high-frequency rTMS (HF-rTMS), its underlying neuronal mechanism remains elusive. Brain entropy (BEN), a measure of irregularity of brain activity, has recently emerged as a novel marker of regional brain activity. Our previous studies have shown the sensitivity of BEN to depression and HF-rTMS, suggesting BEN as a sensitive tool for understanding the brain mechanism of iTBS. To assess this possibility, we calculated BEN using resting state fMRI data provided by an open dataset in OpenNeuro. Sixteen healthy participants underwent 600 pulses of iTBS applied over the left dorsolateral prefrontal cortex (L-DLPFC) at two intensities (90% and 120% of individual resting motor threshold (rMT)) on separate days. We assessed the pre-post stimulation BEN difference and its associations with neurotransmitter receptor and transporter binding maps. Our results showed that subthreshold iTBS (90% rMT) decreased striatal BEN, while suprathreshold iTBS (120% rMT) increased striatal BEN. We also found significant differences in the spatial correlation between BEN changes induced by different stimulation intensities and various neurotransmitters. These results suggest that differences in BEN caused by iTBS stimulation intensity may be related to the release of other neurotransmitters. The study underscores the significance of iTBS stimulation intensity and provides a basis for future clinical investigations to identify stimulation intensities with good therapeutic benefits.

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