FV 7. Cross-sectional area of the vagus nerve correlates with parasympathetic dysfunction in Parkinson's Disease

Huckemann, Sophie; Müller, Katharina; Averdunk, P.; Kühn, Eva; Hilker, L.; Kools, S.; Scholz, L.; Bulut, Yesim; Brünger, Jil; Grüter, Thomas; Fisse, Anna Lena; Motte, Jeremias; Yoon, Min‐Suk; Gold, Ralf; Schneider‐Gold, Christiane; Tönges, Lars; Pitarokoili, K.

doi:10.1016/j.clinph.2021.02.383

Cited by 2 publications

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“…Heart rate variability can be used to assess autonomic nervous system function and is reportedly inversely associated with the CSA of the left VN [31]. Furthermore, atrophy of the VN has been reported in patients with Parkinson’s disease [32] and has been observed to correlate with parasympathetic dysfunction [6]. However, other studies have contradicted these findings [2, 7].…”

Section: Discussionmentioning

confidence: 99%

“…Such conditions include neurodegenerative diseases such as Parkinson's Disease [2][3][4][5][6][7] and amyotrophic lateral sclerosis [8][9][10], neuropathies such as Charcot-Marie-Tooth [11,12], Guillain-Barré syndrome [13], and transthyretin familial amyloid polyneuropathy [14], as well as fibromyalgia [15]. Significant reductions in the CSA of the VN have been observed on the right side [5] or on both sides in Parkinson's disease [3,4,6] and on both sides in ALS [9,10], correlating variably with disease severity and duration and age [3,4,9,10]. However, not all studies have identified differences [2,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Oura

Akasaka

Ishizuka

et al. 2023

Preprint

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Objectives Although the vagus nerve (VN) is easily observed by ultrasonography, few studies have evaluated the cross-sectional area (CSA) of the VN in healthy older individuals from East Asia. In this study, we aimed to report reference values for the CSA of the VN in community-dwelling elderly Japanese individuals and to identify any associated medical history and/or lifestyle factors. Methods The present study included 336 participants aged >= 65 years from a prospective cohort study conducted in Yahaba, Japan from October 2021 to February 2022. The CSA of the VN was measured bilaterally at the level of the thyroid gland by ultrasonography. Univariate and multivariable linear regression analyses were conducted to identify the associations between clinical and background factors and the CSA of the VN on each side. Results In our cohort, the median CSA of the VN was 1.3 mm2 (interquartile range [IQR] 1.1–1.6) on the right side and 1.2 mm2 (IQR 1.0–1.4) on the left side. Multivariable linear regression analysis showed that history of head injury (β = -0.15, p < .01), history of convulsion (β = 0.19, p < .01), and BMI (β = 0.30, p < .01) were independently associated with the CSA of the VN on the left side. In contrast, there were no independent associations between any of the assessed variables and the CSA on the right side. Conclusion We have reported reference VN CSA values for community-dwelling elderly Japanese individuals. In addition, we showed that the CSA of the VN on the left side was positively associated with a history of convulsive seizure and BMI and inversely associated with a history of head injury.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Oura

Akasaka

Ishizuka

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Heart rate variability (HRV) can be used to assess autonomic nervous system function and is reportedly inversely associated with the CSA of the left VN [ 31 ]. Furthermore, atrophy of the VN has been reported in patients with Parkinson’s disease [ 32 ] and has been observed to correlate with parasympathetic dysfunction [ 6 ]. However, other studies have contradicted these findings [ 2 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since then, ultrasonography has been used to assess the cross-sectional area (CSA) of the VN in patients with a variety of neurological conditions in order to investigate potential pathological changes. Such conditions include neurodegenerative diseases such as Parkinson's Disease [2][3][4][5][6][7] and amyotrophic lateral sclerosis [8][9][10], neuropathies such as Charcot-Marie-Tooth [11,12], Guillain-Barre ´syndrome [13], and transthyretin familial amyloid polyneuropathy [14], as well as fibromyalgia [15]. Significant reductions in the CSA of the VN have been observed on the right side [5] or on both sides in Parkinson's disease [3,4,6] and on both sides in ALS [9,10], correlating variably with disease severity and duration and age [3,4,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Such conditions include neurodegenerative diseases such as Parkinson's Disease [2][3][4][5][6][7] and amyotrophic lateral sclerosis [8][9][10], neuropathies such as Charcot-Marie-Tooth [11,12], Guillain-Barre ´syndrome [13], and transthyretin familial amyloid polyneuropathy [14], as well as fibromyalgia [15]. Significant reductions in the CSA of the VN have been observed on the right side [5] or on both sides in Parkinson's disease [3,4,6] and on both sides in ALS [9,10], correlating variably with disease severity and duration and age [3,4,9,10]. However, not all studies have identified differences [2,7,8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

et al. 2023

View full text Add to dashboard Cite

Objectives Although the vagus nerve (VN) is easily observed by ultrasonography, few studies have evaluated the cross-sectional area (CSA) of the VN in healthy older individuals from East Asia. In this study, we aimed to report reference values for the CSA of the VN in community-dwelling elderly Japanese individuals and to identify any associated medical history and/or lifestyle factors. Methods The present study included 336 participants aged ≥ 70 years from a prospective cohort study conducted in Yahaba, Japan from October 2021 to February 2022. The CSA of the VN was measured bilaterally at the level of the thyroid gland by ultrasonography. Simple linear regression analysis and generalized estimating equation were conducted to identify the associations between clinical and background factors and the CSA of the VN. Results In our cohort, the median CSA of the VN was 1.3 mm2 (interquartile range [IQR] 1.1–1.6) on the right side and 1.2 mm2 (IQR 1.0–1.4) on the left side. Generalized estimating equation showed that history of head injury (β = 0.19, p < .01), current smoking habit (β = -0.09, p = .03), and BMI (β = 0.02, p < .01) were independently associated with the CSA of the VN. Conclusion We have reported reference VN CSA values for community-dwelling elderly Japanese individuals. In addition, we showed that the CSA of the VN was positively associated with a history of head injury and BMI and inversely associated with current smoking habit.

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FV 7. Cross-sectional area of the vagus nerve correlates with parasympathetic dysfunction in Parkinson's Disease

Cited by 2 publications

References 0 publications

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

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