This paper presents a Takagi-Sugeno (T-S) fuzzy model-based approach to model and control a rigid spacecraft with flexible antenna. First, the equations of motion of the flexible spacecraft, which are based on Lagrange equations and given in terms of quasi-coordinates and the Rayleigh-Ritz method, are briefly reviewed. Then, the T-S fuzzy modeling and the parallel distributed compensation control technique are introduced. We utilize full state-feedback and optimal H ∞ robustness performance via a T-S fuzzy model to achieve position and attitude stabilization, vibration suppression, and disturbance rejection objectives. Finally, this technique is applied to the flexible spacecraft equations of motion resulting in a nonlinear controller. The controller produces an asymptotically stable closed-loop system which is robust to external disturbances and has a simple structure for straightforward implementation. Numerical simulation is provided for performance evaluation of the proposed controller design.