In this paper, a new robust fuzzy H∞ estimatorbased stabilization design for a class of N -dimensional nonlinear parabolic partial differential systems (PDSs) with either the Dirichlet or Neumann boundary conditions is proposed. First, an N -dimensional parabolic Takagi-Sugeno (T-S) fuzzy PDS is used to approximate the N -dimensional nonlinear parabolic PDS via the knowledge-based T-S fuzzy system technique. Second, based on the N -dimensional parabolic T-S fuzzy PDS, a robust fuzzy estimator-based controller is employed not only to stabilize the PDS, but also to attenuate the effects of external and measurement noises on the PDS in the spatio-temporal domain below a prescribed attenuation level. The robust fuzzy H∞ estimator-based stabilization design problem can be formulated as a diffusion matrix inequality (DMI) problem. To solve DMIs via the traditional algebraic matrix techniques, we utilize the divergence theorem and the Poincaré inequality to transform the DMIs into bilinear matrix inequalities (BMIs) with a Poincaré constant defined according to the spatial domain of the corresponding PDS. Finally, the robust fuzzy H∞ estimator-based stabilization design problem can be effectively solved by a set of linear matrix inequalities (LMIs) instead of the BMIs with the help of the proposed decoupled method. Additionally, an optimal robust fuzzy H∞ estimator-based stabilization design can be realized via minimizing the noise attenuation level. A simulation example is provided to illustrate the design procedure and verify the performance of the proposed optimal design.Index Terms-Fuzzy estimator-based control design; Ndimensional parabolic fuzzy partial differential system; Ndimensional parabolic nonlinear partial differential system; Robust fuzzy H∞ stabilization; Spatio-temporal random noise.