Fuzhuan tea reverses arterial stiffening after modest weight gain in mice

Lee, Dustin M.; Battson, Micah L.; Jarrell, Dillon K.; Cox-York, Kimberly; Foster, Michelle T.; Weir, Tiffany L.; Gentile, Christopher L.

doi:10.1016/j.nut.2016.07.010

Cited by 14 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…80% reduction in maximum dilation), whereas no impairments were found in the carotid arteries. This finding of discrepant function along the arterial tree corroborates previous work from our laboratory and elsewhere that suggests that the mesenteric arteries are more susceptible than the carotid arteries to metabolic disturbances [23,24]. The reasons for this differential susceptibility along the vascular tree are unclear, although one notable difference between mesenteric and carotid arteries is the lack of PVAT that accumulates along the carotid bodies, even in models of extreme obesity such as DB mice.…”

Section: Discussionsupporting

confidence: 88%

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background/Aims: Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), on arterial stiffness and endothelial dysfunction in type 2 diabetic mice. Methods: Carotid and mesenteric artery endothelial function were assessed via ex vivo pressure myography, and arterial stiffness was measured by aortic pulse wave velocity. The effects of TUDCA were examined both acutely (ex vivo) and chronically (250 mg/kg/day; i.p., 4 weeks). Results: Compared to control C57BL/6J mice, db/db (DB) mice did not display carotid artery endothelial dysfunction; however, mesenteric artery endothelial function was markedly impaired. Acute incubation and chronic administration of TUDCA improved endothelium-dependent dilation in DB mesenteric arteries, without affecting endothelium-independent dilation. Chronic TUDCA administration also reduced arterial stiffness and was associated with reductions in ER stress markers in aortic and perivascular adipose tissue. Conclusions: These results suggest that ER stress may represent a novel cause of, and therapeutic target for, diabetic vascular dysfunction.

show abstract

Section: Discussionsupporting

confidence: 88%

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…In recent years, a growing body of animal and human studies showed that dietary supplementation with tea was a potentially viable nutritional strategy for the prevention of obesity . It has been demonstrated that FBT and KDC consumption could prevent weight gain and metabolic disorders induced by HFD feeding . Furthermore, Lactobacillus johnsonii and another Lactobacillus sp.…”

Section: Discussionmentioning

confidence: 99%

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

Chen

Xie

Dai

et al. 2018

Molecular Nutrition Food Res

169

136

View full text Add to dashboard Cite

show abstract

“…Large elastic artery stiffness was determined by aPWV at baseline and following the 8-week intervention as previously described [ 23 , 28 ]. Briefly, mice were anesthetized using 2% isoflurane and oxygen at 2 L/min, placed supine on a heating board with legs secured to ECG electrodes, and maintained at a target heart rate of ~ 450 bpm by adjusting isoflurane concentration.…”

Section: Methodsmentioning

confidence: 99%

“…Vascular function was determined as previously described [ 28 , 29 ]. Briefly, second-order mesenteric arteries were placed in pressure myograph chambers (DMT Inc., Atlanta, GA) containing warm PSS, cannulated onto glass micropipettes and secured with suture.…”

Section: Methodsmentioning

confidence: 99%

SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

Lee

Battson

Jarrell

et al. 2018

Cardiovasc Diabetol

Self Cite

188

149

View full text Add to dashboard Cite

BackgroundType 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose cotransporter 2 inhibitors (SGLT2i) represent the most recently approved class of oral medications for the treatment of T2D, and have been shown to reduce cardiovascular and overall mortality. Although it is currently unclear how SGLT2i decrease cardiovascular risk, an improvement in vascular function is one potential mechanism. The aim of the current study was to examine if dapagliflozin, a widely prescribed STLT2i, improves generalized vascular dysfunction in type 2 diabetic mice. In light of several studies demonstrating a bi-directional relation between orally ingested medications and the gut microbiota, a secondary aim was to determine the effects of dapagliflozin on the gut microbiota.MethodsMale diabetic mice (Db, n = 24) and control littermates (Con; n = 23) were randomized to receive either a standard diet or a standard diet containing dapagliflozin (60 mg dapagliflozin/kg diet; 0.006%) for 8 weeks. Arterial stiffness was assessed by aortic pulse wave velocity; endothelial function and vascular smooth muscle dysfunction were assessed by dilatory responses to acetylcholine and sodium nitroprusside, respectively.ResultsCompared to untreated diabetic mice, diabetic mice treated with dapagliflozin displayed significantly lower arterial stiffness (Db = 469 cm/s vs. Db + dapa = 435 cm/s, p < 0.05), and improvements in endothelial dysfunction (area under the curve [AUC] Db = 57.2 vs. Db + dapa = 117.0, p < 0.05) and vascular smooth muscle dysfunction (AUC, Db = 201.7 vs. Db + dapa = 285.5, p < 0.05). These vascular improvements were accompanied by reductions in hyperglycemia and circulating markers of inflammation. The microbiota of Db and Con mice were distinctly different, and dapagliflozin treatment was associated with minor alterations in gut microbiota composition, particularly in Db mice, although these effects did not conclusively mediate the improvements in vascular function.ConclusionsDapagliflozin treatment improves arterial stiffness, endothelial dysfunction and vascular smooth muscle dysfunction, and subtly alters microbiota composition in type 2 diabetic mice. Collectively, the improvements in generalized vascular function may represent an important mechanism underlying the cardiovascular benefits of SGLT2i treatment.

show abstract

Fuzhuan tea reverses arterial stiffening after modest weight gain in mice

Cited by 14 publications

References 26 publications

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

Contact Info

Product

Resources

About