Fuzhuan brick tea extract prevents diet-induced obesity via stimulation of fat browning in mice

Yoo, Ahyoung; Kim, Min Jung; Ahn, Jiyun; Jung, Chang Hwa; Seo, Hyo Deok; Ly, Sun Yung; Ha, Tae Youl

doi:10.1016/j.foodchem.2021.132006

Cited by 19 publications

(18 citation statements)

References 32 publications

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“…We found that insulin, AKT, and AMPK signalling were afected by HTE, resulting in modulation of the expression levels of lipid and glucose metabolism-related genes. It has been reported that tea or tea products can prevent HFD-induced obesity by several mechanisms, such as activating fat browning [33,34], modulating gut microbiota [35,36], and infuencing lipid metabolism [37]. Our study showed that HTE had signifcant efects on lipid metabolism.…”

Section: Discussionsupporting

confidence: 52%

Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

Wang

Ying

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Tea is one of the most popular beverages in the world. The health-promoting effects of tea and its individual constituents, including antiobesity and antihyperlipidaemia effects, have been well accepted. In this study, we evaluated the effects of herbal tea essence (HTE), a commercial product extracted from black tea, on HFD-induced obesity in mice. HTE effectively reduces the gain in body weight and improves glucose tolerance and insulin sensitivity after HFD treatment. HTE inhibits lipid accumulation in the body and reduces serum lipid contents. Furthermore, HTE negatively regulates the expression levels of genes that control lipogenesis and gluconeogenesis and upregulates the expression of genes for lipid β oxidation. The regulatory effects of HTE on these genes may occur through activation of the AKT, IRS-1, and AMPK signalling pathways. Our observations suggest that HTE could be a promising option for nutritional intervention in the treatment of obesity.

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Section: Discussionsupporting

confidence: 52%

Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

Wang

Ying

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…It has been reported that pu-erh tea dramatically reduced the characteristics of obesity and ameliorated the serum biochemical profile in mice fed an HFD [ 9 ]. In the study of Yoo et al [ 14 ], the administration of Fuzhuan tea extract significantly lowered body weight and adipose tissue mass, and improved serum biochemical parameters and hepatic steatosis concomitant in HFD-fed mice.…”

Section: Resultsmentioning

confidence: 99%

Gut Microbiota Differentially Mediated by Qingmao Tea and Qingzhuan Tea Alleviated High-Fat-Induced Obesity and Associated Metabolic Disorders: The Impact of Microbial Fermentation

Cheng

Gao

et al. 2022

Foods

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Although dark tea is a unique microbial-fermented tea with a high reputation for having an antiobesity effect, little is known about the effect of microbial fermentation on tea leaves’ antiobesity properties. This study compared the antiobesity effects of microbial-fermented Qingzhuan tea (QZT) and unfermented Qingmao tea (QMT), providing insight into their underlying mechanisms associated with gut microbiota. Our results indicated that the supplementation of QMT extract (QMTe) and QZT extract (QZTe) displayed similar antiobesity effects in high-fat diet (HFD)-fed mice, but the hypolipidemic effect of QZTe was significantly stronger than that of QMTe. The microbiomic analysis indicated that QZTe was more effective than QMTe at regulating HFD-caused gut microbiota dysbiosis. Akkermansiaceae and Bifidobacteriaceae, which have negative correlations with obesity, were enhanced notably by QZTe, whereas Faecalibaculum and Erysipelotrichaceae, which are positively correlated with obesity, were decreased dramatically by QMTe and QZTe. A Tax4Fun analysis of QMTe/QZTe-mediated gut microbiota revealed that QMTe supplementation drastically reversed the HFD-induced upregulation of glycolysis and energy metabolism, whereas QZTe supplementation significantly restored the HFD-caused downregulation of pyruvate metabolism. Our findings suggested that microbial fermentation showed a limited effect on tea leaves’ antiobesity, but enhanced their hypolipidemic activity, and QZT could attenuate obesity and associated metabolic disorders by favorably modulating gut microbiota.

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“…At present, research on the lipid-lowering activity of microbial fermented tea is mainly focused on lowering blood lipids and weight loss ( 70 , 71 ). For example, the fu brick tea was fermented by Eurotium cristatum , and the water extract of the fermented fu brick tea was fed to high-fat zebrafish.…”

Section: Changes Of Biological Activity In Tea After Microbial Fermen...mentioning

confidence: 99%

Modulation effects of microorganisms on tea in fermentation

Shi

Qian

2022

Front. Nutr.

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Tea is a popular traditional drink and has been reported to exhibit various health-promoting effects because of its abundance of polyphenols. Among all the tea products, fermented tea accounts for the majority of tea consumption worldwide. Microbiota plays an important role in the fermentation of tea, which involves a series of reactions that modify the chemical constituents and thereby affect the flavor and bioactivities of tea. In the present review, the microorganisms involved in fermented tea and tea extracts in the recent studies were summarized and the modulation effects of microorganisms on tea in fermentation, including polyphenols composition and content, biological activities and sensory characteristics, were also critically reviewed. It is expected that the data summarized could provide some references for the development of microbial fermented tea drinks with specific nutrition and health benefits.

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Fuzhuan brick tea extract prevents diet-induced obesity via stimulation of fat browning in mice

Cited by 19 publications

References 32 publications

Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

Gut Microbiota Differentially Mediated by Qingmao Tea and Qingzhuan Tea Alleviated High-Fat-Induced Obesity and Associated Metabolic Disorders: The Impact of Microbial Fermentation

Modulation effects of microorganisms on tea in fermentation

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