Future Trends in Epilepsy Imaging

Chiu, Andrew; Zeineh, Michael

doi:10.1007/978-3-030-82367-2_45

Cited by 1 publication

(2 citation statements)

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“…Although [ 11 C] 28 PET imaging shows promise, the short half-life of 11 C limits its clinical application . However, the structure of FMZ already contains an F atom, allowing for radiolabeling by replacing the F atom with 18 F without altering the substrate’s structure.…”

Section: F- and 11c-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%

“…Although [ 11 C]28 PET imaging shows promise, the short half-life of 11 C limits its clinical application. 123 However, the structure of FMZ already contains an F atom, allowing for radiolabeling by replacing the F atom with 18 F without altering the substrate's structure. A PET study was conducted on eight male subjects to directly compare the binding of [ 11 C]28 and [ 18 F]FMZ ([ 18 F]28) in the human brain.…”

Section: F-and 11 C-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%

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A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research

Wang

Fan

et al. 2023

J. Med. Chem.

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With appropriate radiotracers, positron emission tomography (PET) allows direct or indirect monitoring of the spatial and temporal distribution of anesthetics, neurotransmitters, and biomarkers, making it an indispensable tool for studying the general anesthesia mechanism. In this Perspective, PET tracers that have been recruited in general anesthesia research are introduced in the following order: 1) 11 C/ 18 F-labeled anesthetics, i.e., PET tracers made from inhaled and intravenous anesthetics; 2) PET tracers targeting anesthesia-related receptors, e.g., neurotransmitters and voltage-gated ion channels; and 3) PET tracers for studying anesthesia-related neurophysiological effects and neurotoxicity. The radiosynthesis, pharmacodynamics, and pharmacokinetics of the above PET tracers are mainly discussed to provide a practical molecular toolbox for radiochemists, anesthesiologists, and those who are interested in general anesthesia.

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Section: F- and 11c-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%

Section: F-and 11 C-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%