Future treatments in hypertension: Can we meet the unmet needs of patients?

Kanbay, Mehmet; Çöpür, Sidar; Tanrıöver, Cem; Ucku, Duygu; Laffin, Luke J.

doi:10.1016/j.ejim.2023.06.008

Cited by 3 publications

(1 citation statement)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tailoring treatment to the patient's individual phenotype and kidney disease cause represents the real future of nephrology. Meanwhile, research has provided us with novel RAAS-inhibiting drug classes [9]. In this review, we discuss the RAAS inhibition system, how it originated and how the novel drugs interfere with the system.…”

Section: Introductionmentioning

confidence: 99%

Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic

Ksiazek,

Hu,

Andò

et al. 2024

IJMS

View full text Add to dashboard Cite

Renin–angiotensin–aldosterone system (RAAS) inhibitors are standard care in patients with hypertension, heart failure or chronic kidney disease (CKD). Although we have studied the RAAS for decades, there are still circumstances that remain unclear. In this review, we describe the evolution of the RAAS and pose the question of whether this survival trait is still necessary to humankind in the present age. We elucidate the benefits on cardiovascular health and kidney disease of RAAS inhibition and present promising novel medications. Furthermore, we address why more studies are needed to establish a new standard of care away from generally prescribing ACEi or ARB toward an improved approach to combine drugs tailored to the needs of individual patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic

Ksiazek,

Hu,

Andò

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

A novel risk factor for malignancy: Albuminuria

Kanbay,

Copur,

Yilmaz

et al. 2023

European Journal of Internal Medicine

View full text Add to dashboard Cite

Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine

Alhamhoom,

Sharma,

Nanjappa

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Nisoldipine (NIS) is a calcium channel blocker that exhibits poor bioavailability (~5%) due to low aqueous solubility and presystemic metabolism in the gut wall. In this context, the present work aimed to develop NIS solid dispersion (NISSD)-based sublingual films using solvent casting technique to improve the dissolution. Phase solubility studies indicated that Soluplus® was the most effective carrier for improving the aqueous solubility of NIS. NISSDs were initially developed using the solvent evaporation method. Fourier transform infrared spectrometric studies were found to display the characteristic vibrational bands related to C=O stretching and N-H deformation in NISSDs, proving the chemical integrity of the drug in NISSDs. Subsequently, bioadhesive sublingual films of NISSDs were formulated using solvent casting method, using hydroxypropyl methyl cellulose (HPMC) E5, E15, and hydroxy ethyl cellulose (HEC EF) as hydrophilic polymers and polyethylene glycol 400 (PEG 400) as plasticizer. The incorporation of NISSDs was found to produce clear films that displayed uniform content. The sublingual film of NISSDs composed of HPMC E5 (2% w/v), was found to display the least thickness (0.29 ± 0.02 mm), the highest folding endurance (168.66 ± 4.50 times), and good bioadhesion strength (12.73 ± 0.503 g/cm2). This film was found to rapidly disintegrate (28.66 ± 3.05 sec) and display near-complete drug release (94.24 ± 1.22) in 30 min. Incorporating NISSDs into rapidly bioadhesive sublingual films considerably improves drug dissolution. Overall, these research outcomes underscored the potential of rapidly dissolving bioadhesive sublingual films to evade gut metabolism and resolve the bioavailability issues associated with oral administration of NIS.

show abstract

Future treatments in hypertension: Can we meet the unmet needs of patients?

Cited by 3 publications

References 139 publications

Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic

Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic

A novel risk factor for malignancy: Albuminuria

Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine

Contact Info

Product

Resources

About