Future Targets for Female Sexual Dysfunction

Abstract

Introduction Female sexual function reflects a dynamic interplay of central and peripheral nervous, vascular, and endocrine systems. The primary challenge in the development of novel treatments for female sexual dysfunction is the identification and targeted modulation of excitatory sexual circuits using pharmacologic treatments that facilitate the synthesis, release, and/or receptor binding of neurochemicals, peptides, and hormones that promote female sexual function. Aim To develop an evidence-based state-of-the-art consensus report that critically integrates current knowledge of the therapeutic potential for known molecular and cellular targets to facilitate the physiologic processes underlying female sexual function. Methods State-of-the-art review representing the opinions of international experts developed in a consensus process during a 1-year period. Main Outcome Measures Expert opinion was established by grading the evidence-based medical literature, intensive internal committee discussion, public presentation, and debate. Results Scientific investigation is urgently needed to expand knowledge and foster development of future treatments that maintain genital tissue integrity, enhance genital physiologic responsiveness, and optimize positive subjective appraisal of internal and external sexual cues. This article critically condenses the current knowledge of therapeutic manipulation of molecular and cellular targets within biological systems responsible for female sexual physiologic function. Conclusion Future treatment targets include pharmacologic modulation of emotional learning circuits, restoration of normal tactile sensation, growth factor therapy, gene therapy, stem cell–based therapies, and regenerative medicine. Concurrent use of centrally and peripherally acting therapies could optimize treatment response.

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

“…In new strategies for treatment of FSD, ability in fibrosis reduction enhances vaginal flexibility and stimulation of vaginal secretion via angiogenesis induction should be considered (Farmer et al, 2016). Based on the ability of PRP in the induction of angiogenesis and tissue regeneration, it seems to be a suitable choice in this area (Mostafaei et al;Mohammadi et al, 2017a;Mohammadi et al, 2017b).…”

“…Platelet related products have been a satisfactory outcome in the treatment of chronic skin and soft tissue lesions and plastic surgeries (Serra-Mestre et al, 2014;Mohammadi et al, 2017a). In new strategies for treatment of FSD, following the cited facets should be considered (Farmer et al, 2016;Carter et al, 2017) • Do not contain hormonal combinations • Able to reduce fibrosis and enhances vaginal flexibility…”

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Advances in Gene Therapy

“…By inserting genes into germ cells genetic information can be transferred to future generations. [12] In this method, regulations and laws and safety should be focused. Like having previous experience of somatic gene therapy and offering safe results and have experience of animal patterns for proofing safety.…”